Clinical Aspects of DWI

Diffusion‐weighted MR imaging (DWI) is capable of imaging ischemia‐induced changes in water protons in either animal or man. Technical developments are described that allow the routine clinical utility of DWI in a stroke setting to provide objective criteria beyond the neurological exam by which the pathophysiology of stroke can be evaluated. To date, DWI has provided unique information concerning detection and evaluation of acute, symptomatic lesions from older, chronic strokes, detection and localization of small deep infarcts and reversible ischemic neurologic deficits and transient ischemia. Clinical DWI studies suggest that the temporal behaviour of ADC can critically improve the evaluation of clinical ischemia.

[1]  M E Moseley,et al.  Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging. , 1996, Radiology.

[2]  R M Weisskoff,et al.  Ultra-fast imaging. , 1991, Magnetic resonance imaging.

[3]  Wei Li,et al.  Fast magnetic resonance diffusion‐weighted imaging of acute human stroke , 1992, Neurology.

[4]  K Minematsu,et al.  Reversible Focal Ischemic Injury Demonstrated by Diffusion‐Weighted Magnetic Resonance Imaging in Rats , 1992, Stroke.

[5]  R. Turner,et al.  Echo-planar imaging: magnetic resonance imaging in a fraction of a second. , 1991, Science.

[6]  M E Moseley,et al.  High-Speed MR Imaging of Ischemic Brain Injury following Stenosis of the Middle Cerebral Artery , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  H. Kantor,et al.  Signal loss induced by superparamagnetic iron oxide particle in NMR spin‐echo images: The role of diffusion , 1990, Magnetic resonance in medicine.

[8]  J. Kucharczyk,et al.  Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy , 1990, Magnetic resonance in medicine.

[9]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[10]  S. Williams,et al.  Diffusion‐Weighted Imaging Studies of Cerebral Ischemia in Gerbils: Potential Relevance to Energy Failure , 1992, Stroke.

[11]  B. Siewert,et al.  Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging , 1995, Annals of neurology.

[12]  P van Gelderen,et al.  Water diffusion and acute stroke , 1994, Magnetic resonance in medicine.

[13]  R. Ordidge,et al.  Magnetic Resonance Imaging Assessment of Evolving Focal Cerebral Ischemia Comparison With Histopathology in Rats , 1994, Stroke.

[14]  G. Mckinnon.  Ultrafast interleaved gradient‐echo‐planar imaging on a standard scanner , 1993, Magnetic resonance in medicine.

[15]  M. Chopp,et al.  Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion , 1993, Journal of the Neurological Sciences.

[16]  Bruce R. Rosen,et al.  MR Diffusion Imaging of the Human Brain , 1990, Journal of computer assisted tomography.

[17]  M E Moseley,et al.  Comparison of diffusion‐ and T2‐weighted MRI for the early detection of cerebral ischemia and reperfusion in rats , 1991, Magnetic resonance in medicine.

[18]  A. D. de Crespigny,et al.  Navigated Diffusion Imaging of Normal and Ischemic Human Brain , 1995, Magnetic resonance in medicine.

[19]  J. Felmlee,et al.  Echo-planar imaging of the liver with a standard MR imaging system. , 1993, Radiology.

[20]  G M Bydder,et al.  MR Imaging: Clinical Use of the Inversion Recovery Sequence , 1985, Journal of computer assisted tomography.

[21]  R A Knight,et al.  Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. , 1991, Stroke.

[22]  J C Gore,et al.  Analysis and correction of motion artifacts in diffusion weighted imaging , 1994, Magnetic resonance in medicine.

[23]  A. Song,et al.  Optimized isotropic diffusion weighting , 1995, Magnetic resonance in medicine.

[24]  R. Turner,et al.  Diffusion MR imaging: clinical applications. , 1992, AJR. American journal of roentgenology.

[25]  J. Pauly,et al.  Diffusion‐weighted interleaved echo‐planar imaging with a pair of orthogonal navigator echoes , 1996, Magnetic resonance in medicine.