论文信息 - Synthesis of 1-(tetrahydrofuran-2-yl)-5-fluorouracil-2-14C) (ftorafur-2-14C)

Synthesis of 1-(tetrahydrofuran-2-yl)-5-fluorouracil-2-14C) (ftorafur-2-14C)

The synthesis of 1-(tetrahydrofuran-2-yl)-5-fluorouracil-2-14C (Ftorafur-2-14C) has been accomplished by the condensation of 5-fluorouracil-2-14C and 2-chlorotetrahydrofuran using a procedure developed in our laboratory.

L. Townsend | A. M. Cohen | Steven J. Manning

[1] A. Goldin,et al. Comparison of 5-fluorouracil and ftorafur. I. Quantitative and qualitative differences in toxicity to mice. , 1976, Cancer treatment reports.

[2] A. Goldin,et al. Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors. , 1976, Cancer treatment reports.

[3] E. Freireich,et al. Clinical evaluation of ftorafur (pyrimidine-deoxyribose n1-2'-furanidyl-5-fluorouracil). , 1976, Cancer research.

[4] C. Smart,et al. Phase I study of ftorafur, an analog of 5‐fluorouracil , 1975, Cancer.

[5] A. M. Cohen. The disposition of ftorafur in rats after intravenous administration. , 1975, Drug metabolism and disposition: the biological fate of chemicals.

[6] D. Kessel,et al. In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil. , 1975, Cancer research.

[7] I. Hršak,et al. Comparison of the effects of 5-fluorouracil and Ftorafur on the haematopoiesis in mice. , 1974, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

[8] M. Klvaňa,et al. Experience with furanidyl-fluorouracil in advanced tumours of the breast. , 1974, Neoplasma (Bratislava).

[9] A. Garin,et al. Results of treatment of malignant tumors with ftorafur , 1972, Cancer.

[10] Smolyanskaya Az,et al. To biological activity of antitumour antimetabolite "ftorafur". , 1972 .

[11] Karev Ni,et al. Experience with ftorafur treatment in breast cancer. , 1972 .