Human fetal exposure to ochratoxin A and aflatoxins.

Analysis of 64 cord blood samples from pregnant women in Sierra Leone revealed the presence of ochratoxin A (OTA) and aflatoxins in 25% and 58% of samples, respectively. Of the eight maternal blood samples collected during delivery, one contained OTA and aflatoxins were detected in six. There was no relationship between mycotoxins in maternal and cord blood. The effect these toxins might have had on the birthweight of infants is discussed.

[1]  I. Purchase,et al.  Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. , 1985, British Journal of Cancer.

[2]  R. Hendrickse,et al.  Aflatoxins in human breast milk. , 1984, Annals of tropical paediatrics.

[3]  S H Gilani,et al.  Teratogenicity of ochratoxin A in chick embryos. , 1978, Toxicology and applied pharmacology.

[4]  L. Salamat,et al.  A case-control dietary study of primary liver cancer risk from aflatoxin exposure. , 1982, International journal of epidemiology.

[5]  R. Hendrickse,et al.  Aflatoxins in breast milk, neonatal cord blood, and serum of pregnant women , 1988, British medical journal.

[6]  A. Hall,et al.  Aflatoxin-albumin adducts in human sera from different regions of the world. , 1990, Carcinogenesis.

[7]  G. Szczech,et al.  Teratogenic and toxic effects of ochratoxin A in rats. , 1976, Toxicology and applied pharmacology.

[8]  K. Hult,et al.  Ochratoxin A in pig blood: method of analysis and use as a tool for feed studies , 1979, Applied and environmental microbiology.

[9]  F. Jonsyn Fungi associated with selected fermented foods in Sierra Leone , 1989 .

[10]  S. Maxwell,et al.  Foetal and Neonatal Exposure to Aflatoxins , 1989, Acta paediatrica Scandinavica.

[11]  G. Szczech,et al.  Postnatal behavioral effects of ochratoxin A in offspring of treated mice. , 1983, Teratology.

[12]  L. Appelgren,et al.  Distribution of 14C-labelled ochratoxin A in pregnant mice. , 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[13]  E. Märtlbauer,et al.  Determination of ochratoxin A in human milk , 1988 .

[14]  S. Maxwell,et al.  Aflatoxins in Breast Milk, Neonatal Cord Blood and Sera of Pregnant Women , 1989 .

[15]  F. Jonsyn,et al.  Mycotoxic flora and mycotoxins in smoke-dried fish from Sierra Leone. , 1992, Die Nahrung.

[16]  A. Hall,et al.  Aflatoxin M1 in human breast milk from The Gambia, west Africa, quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC. , 1992, Carcinogenesis.

[17]  L. Hsieh,et al.  Detection of aflatoxin B1-DNA adducts in human placenta and cord blood. , 1993, Cancer research.

[18]  J. DiPaolo,et al.  Teratogenic Response by Hamsters, Rats and Mice to Aflatoxin B1 , 1967, Nature.

[19]  J. D. May,et al.  The individual and combined effects of aflatoxin and ochratoxin A on various processing parameters of broiler chickens. , 1984, Poultry science.

[20]  L. Kubena,et al.  ASSESSMENT OF THE DISTRIBUTION AND ELIMINATION OF OCHRATOXIN A IN THE PREGNANT RAT , 1986 .

[21]  T. Kamataki,et al.  Metabolic activation of aflatoxin B1 and 2-amino-3-methylimidazo[4,5-f]-quinoline by human adult and fetal livers. , 1990, Cancer research.

[22]  B. Henderson,et al.  Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. , 1989, Cancer research.

[23]  J. Bauer,et al.  Bestimmung von Ochratoxin A in Muttermilch , 1988 .

[24]  Y. Fukui,et al.  Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain. , 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[25]  A. Hall,et al.  In-utero exposure to aflatoxin in West Africa , 1991, The Lancet.

[26]  D. Denning,et al.  Transplacental transfer of aflatoxin in humans. , 1990, Carcinogenesis.

[27]  A. Hayes,et al.  Prenatal effects of Ochratoxin A in hamsters. , 1976, Teratology.