Shear Wave Elastography Quantifies Stiffness in Ex Vivo Porcine Artery with Stiffened Arterial Region.

Five small porcine aortas were used as a human carotid artery model, and their stiffness was estimated using shear wave elastography (SWE) in the arterial wall and a stiffened artery region mimicking a stiff plaque. To optimize the SWE settings, shear wave bandwidth was measured with respect to acoustic radiation force push length and number of compounded angles used for motion detection with plane wave imaging. The mean arterial wall and simulated plaque shear moduli varied from 41 ± 5 to 97 ± 10 kPa and from 86 ± 13 to 174 ± 35 kPa, respectively, over the pressure range 20-120 mmHg. The results revealed that a minimum bandwidth of approximately 1500 Hz is necessary for consistent shear modulus estimates, and a high pulse repetition frequency using no image compounding is more important than a lower pulse repetition frequency with better image quality when estimating arterial wall and plaque stiffness using SWE.

[1]  David Larsson,et al.  Arterial Stiffness Estimation by Shear Wave Elastography: Validation in Phantoms with Mechanical Testing. , 2016, Ultrasound in medicine & biology.

[2]  N. Davis.  Atherosclerosis--an inflammatory process. , 2005, Journal of Insurance Medicine.

[3]  C. Vlachopoulos,et al.  Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness , 2011 .

[4]  G. McVeigh,et al.  Arterial stiffness: clinical relevance, measurement and treatment. , 2007, Clinical science.

[5]  James F. Greenleaf,et al.  Phase Aberration and Attenuation Effects on Acoustic Radiation Force-Based Shear Wave Generation , 2016, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[6]  R. Panerai,et al.  Shear wave elastography assessment of carotid plaque stiffness: in vitro reproducibility study. , 2014, Ultrasound in medicine & biology.

[7]  M. Horsfield,et al.  Dynamic variations in the ultrasound greyscale median of carotid artery plaques , 2013, Cardiovascular Ultrasound.

[8]  Guy Cloutier,et al.  Noninvasive vascular elastography for carotid artery characterization on subjects without previous history of atherosclerosis. , 2008, Medical physics.

[9]  J. Greenleaf,et al.  Material property estimation for tubes and arteries using ultrasound radiation force and analysis of propagating modes. , 2011, The Journal of the Acoustical Society of America.

[10]  Roman Sztajzel,et al.  Contrast-enhanced ultrasound imaging of carotid plaque neo-vascularization: accuracy of visual analysis. , 2014, Ultrasound in medicine & biology.

[11]  Lucian Calmac,et al.  Imaging Atherosclerosis by Carotid Intima-media Thickness in vivo: How to, Where and in Whom ? , 2012, Maedica.

[12]  E. Boerwinkle,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. , 2003, Circulation.

[13]  M. Dichgans,et al.  Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax , 2013, Neurology.

[14]  J. Easton,et al.  Carotid endarterectomy: Trials and tribulations , 1994, Annals of neurology.

[15]  Dalin Tang,et al.  3D MRI-Based Multicomponent FSI Models for Atherosclerotic Plaques , 2004, Annals of Biomedical Engineering.

[16]  Guy Cloutier,et al.  Ultrasound dynamic micro-elastography applied to the viscoelastic characterization of soft tissues and arterial walls. , 2010, Ultrasound in medicine & biology.

[17]  M. Anzidei,et al.  Imaging of the Carotid Artery Vulnerable Plaque , 2014, CardioVascular and Interventional Radiology.

[18]  J.T. Powers,et al.  An axial velocity estimator for ultrasound blood flow imaging, based on a full evaluation of the Doppler equation by means of a two-dimensional autocorrelation approach , 1995, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[19]  Caro Cg,et al.  Observations on pulse wave velocity and pulsatile blood pressure in the human pulmonary circulation. , 1962 .

[20]  M. Mokin,et al.  Cervical carotid artery stenosis: latest update on diagnosis and management. , 2012, Current problems in cardiology.

[21]  Gregg E. Trahey,et al.  Ultrasound Shear Wave Elasticity Imaging Quantifies Coronary Perfusion Pressure Effect on Cardiac Compliance , 2015, IEEE Transactions on Medical Imaging.

[22]  James F. Greenleaf,et al.  Comb-Push Ultrasound Shear Elastography (CUSE) for Evaluation of Thyroid Nodules: Preliminary In Vivo Results , 2015, IEEE Transactions on Medical Imaging.

[23]  A. Mahmoud,et al.  Noninvasive detection of lipids in atherosclerotic plaque using ultrasound thermal strain imaging: in vivo animal study. , 2013, Journal of the American College of Cardiology.

[24]  M. Fink,et al.  Viscoelastic and anisotropic mechanical properties of in vivo muscle tissue assessed by supersonic shear imaging. , 2010, Ultrasound in medicine & biology.

[25]  R D Kamm,et al.  Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels. , 1992, Circulation research.

[26]  E. Maksuti,et al.  Shear wave elastography plaque characterization with mechanical testing validation: a phantom study , 2015, Physics in medicine and biology.

[27]  J. A. Hossack,et al.  Assessing and improving acoustic radiation force image quality using a 1.5-D transducer design , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[28]  Armando Manduca,et al.  Improved Shear Wave Motion Detection Using Pulse-Inversion Harmonic Imaging With a Phased Array Transducer , 2013, IEEE Transactions on Medical Imaging.

[29]  Pengfei Zhang,et al.  Atherosclerotic plaque components characterization and macrophage infiltration identification by intravascular ultrasound elastography based on b-mode analysis: validation in vivo , 2010, The International Journal of Cardiovascular Imaging.

[30]  Caterina M Gallippi,et al.  Non-invasive in vivo characterization of human carotid plaques with acoustic radiation force impulse ultrasound: comparison with histology after endarterectomy. , 2015, Ultrasound in medicine & biology.

[31]  A. Naylor,et al.  Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. , 2007, Journal of vascular surgery.

[32]  P. Carson,et al.  Superficial ultrasound shear wave speed measurements in soft and hard elasticity phantoms: repeatability and reproducibility using two ultrasound systems , 2015, Pediatric Radiology.

[33]  P. Dobrin,et al.  Biaxial anisotropy of dog carotid artery: estimation of circumferential elastic modulus. , 1986, Journal of biomechanics.

[34]  Carlo Catalano,et al.  Imaging of the carotid artery. , 2012, Atherosclerosis.

[35]  R. Virmani,et al.  Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. , 1996, Journal of vascular surgery.

[36]  M. Fink,et al.  Quantitative viscoelasticity mapping of human liver using supersonic shear imaging: preliminary in vivo feasibility study. , 2009, Ultrasound in medicine & biology.

[37]  K. Nightingale,et al.  On the precision of time-of-flight shear wave speed estimation in homogeneous soft solids: initial results using a matrix array transducer , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[38]  Jason D. Allen,et al.  The development and potential of acoustic radiation force impulse (ARFI) imaging for carotid artery plaque characterization , 2011, Vascular medicine.

[39]  Douglas M Dumont,et al.  Acoustic radiation force impulse imaging of vulnerable plaques: a finite element method parametric analysis. , 2013, Journal of biomechanics.

[40]  J. R. Doherty,et al.  Acoustic radiation force elasticity imaging in diagnostic ultrasound , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[41]  Nicolas Grenier,et al.  Supersonic shear wave elastography of in vivo pig kidney: influence of blood pressure, urinary pressure and tissue anisotropy. , 2012, Ultrasound in medicine & biology.

[42]  H. W. Weizsäcker,et al.  Isotropy and anisotropy of the arterial wall. , 1988, Journal of biomechanics.

[43]  K. Nightingale,et al.  Quantifying hepatic shear modulus in vivo using acoustic radiation force. , 2008, Ultrasound in medicine & biology.

[44]  B. Norrving,et al.  Global atlas on cardiovascular disease prevention and control. , 2011 .

[45]  E. Konofagou,et al.  Pulse wave imaging of the human carotid artery: an in vivo feasibility study , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[46]  M. Fink,et al.  Quantitative assessment of arterial wall biomechanical properties using shear wave imaging. , 2010, Ultrasound in medicine & biology.

[47]  K V Ramnarine,et al.  Shear Wave Elastography May Be Superior to Greyscale Median for the Identification of Carotid Plaque Vulnerability: A Comparison with Histology , 2015, Ultraschall in der Medizin.

[48]  D. Sackett,et al.  Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. , 1998, The New England journal of medicine.

[49]  J. D’hooge,et al.  Ultrasound speckle tracking strain estimation of in vivo carotid artery plaque with in vitro sonomicrometry validation. , 2015, Ultrasound in medicine & biology.

[50]  D. Bergel,et al.  The dynamic elastic properties of the arterial wall , 1961, The Journal of physiology.

[51]  M. Bown,et al.  Features of unstable carotid plaque during and after the hyperacute period following TIA/stroke. , 2013, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[52]  M. Fink,et al.  Coherent plane-wave compounding for very high frame rate ultrasonography and transient elastography , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[53]  Antonio Colombo,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. , 2003, Circulation.

[54]  Thomas Deffieux,et al.  Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging. , 2008, Ultrasound in medicine & biology.