Immunocytological and immunochemical analysis on the common acute lymphoblastic leukemia antigen (CALLA): evidence that CALLA on ALL cells and granulocytes are structurally related.

The common acute lymphoblastic leukemia antigen(CALLA) on acute lymphoblastic leukemia(ALL) cells and granulocytes were compared by newly developed and other anti-CALLA monoclonal antibodies(anti-CALLA). New anti-CALLA(IF-3 through IF-7) were effectively selected by immunostaining on kidney sections. By competitive binding three antigenic determinants were separated on ALL cells by IF and other anti-CALLA. All three determinants existed on granulocytes although the reactivity of each anti-CALLA was variable. Such a variability was partly due to the heterogeneous terminal sialic acid compositions. Although CALLA from granulocytes and ALL cells differed in molecular weight they showed identical peptide mapping patterns. These results strongly suggest that CALLA on ALL cells and granulocytes are structurally related although they are different in posttransulational modification.

[1]  Y. Ueyama,et al.  Differentiation antigens defined by mouse monoclonal antibodies against human germ cell tumors. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[2]  T. Lebien,et al.  Structure/function studies of the common acute lymphoblastic leukemia antigen (CALLA/CD10) expressed on human neutrophils. , 1986, Journal of immunology.

[3]  K. Foon,et al.  Immunologic classification of leukemia and lymphoma. , 1986, Blood.

[4]  J. Fujimoto,et al.  Human T lymphocytes and monocytes bear the same Leu-3(T4) antigen. , 1986, Journal of immunology.

[5]  P. Hoffman,et al.  Anti-CALLA antibodies identify unique antigens on lymphoid cells and granulocytes. , 1986, Blood.

[6]  T. Takami,et al.  Two distinct antigen systems in human B lymphocytes: identification of cell surface and intracellular antigens using monoclonal antibodies. , 1984, Clinical and experimental immunology.

[7]  J. Fujimoto,et al.  Immunochemical analysis of the released Leu-2 (T8) molecule , 1984, The Journal of experimental medicine.

[8]  R. Warnke,et al.  A unique human B lymphocyte antigen defined by a monoclonal antibody. , 1984, Hybridoma.

[9]  W. V. Voorhis,et al.  Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[10]  D. Heumann,et al.  Expression of common acute lymphoblastic leukemia antigen (CALLA) on human malignant melanoma cell lines. , 1983, Journal of immunology.

[11]  Sutherland,et al.  Selective expression of the common acute lymphoblastic leukemia (gp 100) antigen on immature lymphoid cells and their malignant counterparts , 1983 .

[12]  J. Hansen,et al.  Granulocytes and cultured human fibroblasts express common acute lymphoblastic leukemia-associated antigens , 1983 .

[13]  W. Leonard,et al.  Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen , 1983, The Journal of experimental medicine.

[14]  A. Michael,et al.  Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens , 1983, The Journal of experimental medicine.

[15]  D. Boue,et al.  Antibody affinity may influence antigenic modulation of the common acute lymphoblastic leukemia antigen in vitro. , 1982, Journal of immunology.

[16]  T. Waldmann,et al.  Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[17]  M. Borowitz,et al.  Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues , 1981, The Journal of experimental medicine.

[18]  H. Lazarus,et al.  A monoclonal antibody to human acute lymphoblastic leukaemia antigen , 1980, Nature.

[19]  T. Lister,et al.  Antisera to acute lymphoblastic leukemia cells. , 1975, Clinical immunology and immunopathology.

[20]  D. Haustein.  Effective radioiodination by lactoperoxidase and solubilisation of cell-surface proteins of cultured murine T lymphoma cells. , 1975, Journal of immunological methods.

[21]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.