Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

[1]  A. Iyer,et al.  Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production. , 2009, Blood.

[2]  Joonsoo Kang,et al.  Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo , 2009, Proceedings of the National Academy of Sciences.

[3]  Y. Zhuang,et al.  Id3 Restricts the Developmental Potential of γδ Lineage during Thymopoiesis1 , 2009, The Journal of Immunology.

[4]  Mark M. Davis,et al.  Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. , 2008, Immunity.

[5]  Sunny Shin,et al.  An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells , 2008, Nature Immunology.

[6]  A. Krueger,et al.  T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis , 2008, The Journal of experimental medicine.

[7]  C. Murre,et al.  Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. , 2007, Immunity.

[8]  M. Ciofani,et al.  Early Growth Response 1 and NF-ATc1 Act in Concert to Promote Thymocyte Development beyond the β-Selection Checkpoint1 , 2007, The Journal of Immunology.

[9]  Y. Zhuang,et al.  E2A and HEB Are Required to Block Thymocyte Proliferation Prior to Pre-TCR Expression1 , 2007, The Journal of Immunology.

[10]  A. Hayday,et al.  Key factors in the organized chaos of early T cell development , 2007, Nature Immunology.

[11]  Joonsoo Kang,et al.  Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13 , 2007, Science.

[12]  M. Ciofani,et al.  Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. , 2007, Journal of immunology.

[13]  Joonsoo Kang,et al.  Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. , 2007, Science.

[14]  M. Ciofani,et al.  Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation , 2006 .

[15]  Isaac Engel,et al.  Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Krueger,et al.  Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate , 2006, The Journal of experimental medicine.

[17]  C. Murre,et al.  Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals. , 2006, Immunity.

[18]  Hiroshi Kawamoto,et al.  E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment , 2006, The Journal of experimental medicine.

[19]  M. Ciofani,et al.  Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. , 2006, Immunity.

[20]  C. Murre.  Helix-loop-helix proteins and lymphocyte development , 2005, Nature Immunology.

[21]  M. Carleton,et al.  Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage , 2005 .

[22]  P. Love,et al.  TCR Signal Strength Influences αβ/γδ Lineage Fate , 2005 .

[23]  A. Hayday,et al.  Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors , 2005, Science.

[24]  P. Love,et al.  TCR signal strength influences alphabeta/gammadelta lineage fate. , 2005, Immunity.

[25]  M. Carleton,et al.  Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. , 2005, Immunity.

[26]  L. Nie,et al.  Notch-Induced E2A Degradation Requires CHIP and Hsc70 as Novel Facilitators of Ubiquitination , 2004, Molecular and Cellular Biology.

[27]  Thomas M. Schmitt,et al.  Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation1 , 2004, The Journal of Immunology.

[28]  Freddy Radtke,et al.  Notch regulation of lymphocyte development and function , 2004, Nature Immunology.

[29]  C. Murre,et al.  E2A proteins enforce a proliferation checkpoint in developing thymocytes , 2004, The EMBO journal.

[30]  Min Xu,et al.  Notch‐induced E2A ubiquitination and degradation are controlled by MAP kinase activities , 2003, The EMBO journal.

[31]  A. Hayday,et al.  The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells , 2003, Nature Immunology.

[32]  M. Toribio,et al.  Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture. , 2003, Blood.

[33]  J. Alberola-Ila,et al.  A Notch so simple influence on T cell development. , 2003, Seminars in cell & developmental biology.

[34]  M. Ciofani,et al.  Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells 1 , 2003, The Journal of Immunology.

[35]  A. Hayday,et al.  The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. , 2003, Nature immunology.

[36]  P. Linsley,et al.  Early Growth Response Transcription Factors Are Required for Development of CD4−CD8− Thymocytes to the CD4+CD8+ Stage1 , 2002, The Journal of Immunology.

[37]  Allan Jones,et al.  Early Growth Response Transcription Factors Are Required for Development of CD4 CD8 Thymocytes to the CD4 CD8 Stage , 2002 .

[38]  M. Kloc,et al.  Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis. , 2002, Differentiation; research in biological diversity.

[39]  H. Macdonald,et al.  Tissue‐specific segregation of TCRγ δ+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR α β+NKT cells , 2001 .

[40]  C. Murre,et al.  Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity , 2001, The Journal of experimental medicine.

[41]  H. Macdonald,et al.  Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells. , 2001, European journal of immunology.

[42]  R. Barndt,et al.  Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB , 2000, Molecular and Cellular Biology.

[43]  C. Murre,et al.  Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. , 2000, Immunity.

[44]  J. Frederick,et al.  Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene , 1999, Molecular and Cellular Biology.

[45]  C. Murre,et al.  Positive and Negative Regulation of  V(D)J Recombination by the E2A Proteins , 1999, The Journal of experimental medicine.

[46]  S. Artavanis-Tsakonas,et al.  Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway , 1998, Molecular and Cellular Biology.

[47]  J D Norton,et al.  Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation , 1997, Molecular and cellular biology.

[48]  T. Miyazaki.  Two Distinct Steps during Thymocyte Maturation from CD4−CD8− to CD4+CD8+ Distinguished in the Early Growth Response (Egr)-1 Transgenic Mice with a Recombinase-activating Gene–Deficient Background , 1997, The Journal of experimental medicine.

[49]  F. Chan,et al.  Functional redundancy of the Nur77 and Nor‐1 orphan steroid receptors in T‐cell apoptosis , 1997, The EMBO journal.

[50]  B. Fowlkes,et al.  Notch activity influences the alphabeta versus gammadelta T cell lineage decision. , 1997, Cell.

[51]  B. Fowlkes,et al.  Notch Activity Influences the αβ versus γδ T Cell Lineage Decision , 1997, Cell.

[52]  G. Stark,et al.  Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo , 1997, The EMBO journal.

[53]  A. Hayday,et al.  α β and γ δ T cells can share a late common precursor , 1995, Current Biology.

[54]  A. Hayday,et al.  Alpha beta and gamma delta T cells can share a late common precursor. , 1995, Current biology : CB.

[55]  L. Schwartz,et al.  Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77 , 1994, Nature.

[56]  S. Tonegawa,et al.  Blockade of transgenic gamma delta T cell development in beta 2‐microglobulin deficient mice. , 1992, The EMBO journal.

[57]  Y. Chien,et al.  Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors. , 1991, Science.