An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1.

[1]  J. Loeffler,et al.  Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity? , 2012, Front. Microbio..

[2]  M. Wink,et al.  Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents , 2012, Front. Microbio..

[3]  M. Wink,et al.  Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[4]  Sagar Agarwal,et al.  Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up. , 2011, Current pharmaceutical design.

[5]  Zhen-ye Xu,et al.  [Effects of chemotherapy combined with Chinese herbal medicine Kangliu Zengxiao decoction on tumor markers of patients with advanced non-small-cell lung cancer: a randomized, controlled trial]. , 2011, Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.

[6]  H. Uno,et al.  Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999 , 2010 .

[7]  Hyunsuk Shim,et al.  Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. , 2010, Biochemical pharmacology.

[8]  T. He,et al.  A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity. , 2009, Oncology reports.

[9]  P. Dimitrova,et al.  Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine. , 2009, Fitoterapia.

[10]  M. Wink,et al.  Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[11]  A. Calcagno,et al.  Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. , 2008, Current molecular pharmacology.

[12]  Huan Wang,et al.  Chinese herbs of Shenghe Powder reverse multidrug resistance of gastric carcinoma SGC-7901. , 2007, Integrative cancer therapies.

[13]  G. Fan,et al.  Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD. , 2007, Journal of pharmaceutical and biomedical analysis.

[14]  S. Ambudkar,et al.  Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin , 2007, Molecular and Cellular Biochemistry.

[15]  Shoei‐Sheng Lee,et al.  Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats. , 2006, Planta medica.

[16]  F. de Longueville,et al.  Microarray-based Detection of Multidrug Resistance in Human Tumor Cells by Expression Profiling of ATP-binding Cassette Transporter Genes , 2004, Cancer Research.

[17]  John N Weinstein,et al.  Analysis of ATP-Binding Cassette Transporter Expression in Drug-Selected Cell Lines by a Microarray Dedicated to Multidrug Resistances⃞ , 2004, Molecular Pharmacology.

[18]  Z. Sauna,et al.  The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1). , 2004, Molecular pharmacology.

[19]  S. Cole,et al.  The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. , 2004, Current drug metabolism.

[20]  T. Fojo,et al.  The role of ABC transporters in clinical practice. , 2003, The oncologist.

[21]  E. Solary,et al.  Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia. , 2003, Blood.

[22]  A. Schinkel,et al.  Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. , 2003, Advanced drug delivery reviews.

[23]  D. Rigal,et al.  Transcriptional regulators of the human multidrug resistance 1 gene: recent views. , 2002, Biochemical pharmacology.

[24]  M. Caligiuri,et al.  Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. , 2002, Blood.

[25]  F H Hausheer,et al.  Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[26]  C. Vergely,et al.  In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. , 1993, Cancer research.

[27]  Lu Yang Prevention and Treatment of Cancer Recurrence and Metastasis in Promoting Blood Circulation to Remove Blood Stasis , 2011 .

[28]  Z. Jie Observation of Clinical Efficacy of Fuzheng Jianpi Decoction Combined with Chemotherapy in Treatment of Advanced Colorectal Cancer , 2011 .

[29]  M. Gottesman Mechanisms of cancer drug resistance. , 2002, Annual review of medicine.

[30]  E. Lissi,et al.  Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. , 1995, Pharmacological research.

[31]  R. Irwin,et al.  The effects of drugs on cough. , 1987, European journal of respiratory diseases. Supplement.