The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses

Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified–case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 μg/m3 increment in SO2 level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2 and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case–crossover analysis displayed greater variation than that from the time-series analysis.

[1]  J. Schwartz,et al.  The temporal pattern of respiratory and heart disease mortality in response to air pollution. , 2003, Environmental health perspectives.

[2]  R. Burnett,et al.  Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. , 2002, JAMA.

[3]  D. Dockery,et al.  Health Effects of Fine Particulate Air Pollution: Lines that Connect , 2006, Journal of the Air & Waste Management Association.

[4]  D. Dockery,et al.  Air pollution and daily mortality in residential areas of Beijing, China. , 1994, Archives of environmental health.

[5]  Thomas Lumley,et al.  Referent Selection in Case-Crossover Analyses of Acute Health Effects of Air Pollution , 2001, Epidemiology.

[6]  Howard M Kipen,et al.  Acute effects of motor vehicle traffic‐related air pollution exposures on measures of oxidative stress in human airways , 2010, Annals of the New York Academy of Sciences.

[7]  F Forastiere,et al.  Air pollution and hospital admissions for respiratory conditions in Rome, Italy. , 2001, The European respiratory journal.

[8]  Daniel Krewski,et al.  Acute Effects of Ambient Particulate Matter on Mortality in Europe and North America: Results from the APHENA Study , 2008, Environmental health perspectives.

[9]  M. Maclure.  The case-crossover design: a method for studying transient effects on the risk of acute events. , 1991, American journal of epidemiology.

[10]  J. Goldsmith,et al.  AIR POLLUTION AND DAILY MORTALITY , 1961, The American journal of the medical sciences.

[11]  J Schwartz,et al.  Air pollution and daily mortality in Birmingham, Alabama. , 1993, American journal of epidemiology.

[12]  P. Burney,et al.  PM10 oxidative properties and asthma and COPD. , 2014, Epidemiology.

[13]  B. Brunekreef,et al.  Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study. , 2009, Research report.

[14]  Marc Saez,et al.  Analysis of Case-Crossover Designs Using Longitudinal Approaches: A Simulation Study , 2005, Epidemiology.

[15]  J. Jaakkola,et al.  Case-crossover design in air pollution epidemiology , 2003, European Respiratory Journal.

[16]  C. Chan,et al.  Air pollution in mega cities in China , 2008 .

[17]  Chen Guo-hai.  A Time-series Study on the Relationship Between Gaseous Air Pollutants and Daily Mortality in Shanghai , 2006 .

[18]  Yuming Guo,et al.  The short-term effect of air pollution on cardiovascular mortality in Tianjin, China: comparison of time series and case-crossover analyses. , 2010, The Science of the total environment.

[19]  D. Briggs,et al.  Outdoor air concentrations of nitrogen dioxide and sulfur dioxide and prevalence of wheezing in school children. , 2000, Epidemiology.

[20]  A. Peters,et al.  Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association , 2010, Circulation.

[21]  L. Tian,et al.  Association between Air Pollutants and Cardiovascular Disease Mortality in Wuhan, China , 2015, International journal of environmental research and public health.

[22]  D. Strachan,et al.  Air pollution and daily mortality in London: 1987-92 , 1996, BMJ.

[23]  Thomas Lumley,et al.  Case–Crossover Analyses of Air Pollution Exposure Data: Referent Selection Strategies and Their Implications for Bias , 2005, Epidemiology.

[24]  J. L. Regens,et al.  Ambient air pollution and daily pediatric hospitalizations for asthma. , 2007, Environmental science and pollution research international.

[25]  F. Dominici,et al.  On the use of generalized additive models in time-series studies of air pollution and health. , 2002, American journal of epidemiology.

[26]  Ambient Air Pollution and Daily Pediatric Hospitalizations for Asthma (5 pp) , 2007 .

[27]  M. Green.  Air pollution and health , 1995 .

[28]  Roger D. Peng,et al.  Statistical Methods for Environmental Epidemiology with R: A Case Study in Air Pollution and Health , 2008 .

[29]  N Künzli,et al.  Public-health impact of outdoor and traffic-related air pollution: a European assessment , 2000, The Lancet.

[30]  R. Burnett,et al.  Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease , 2003, Circulation.

[31]  Yun-Chul Hong,et al.  PM10 Exposure and Non-accidental Mortality in Asian Populations: A Meta-analysis of Time-series and Case-crossover Studies , 2013, Journal of preventive medicine and public health = Yebang Uihakhoe chi.

[32]  Joel Schwartz,et al.  Simultaneous immunisation with influenza vaccine and pneumococcal polysaccharide vaccine in patients with chronic respiratory disease , 1997, BMJ.

[33]  Bert Brunekreef,et al.  Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study , 2002, The Lancet.

[34]  Lidia Morawska,et al.  Respiratory health effects of diesel particulate matter , 2012, Respirology.

[35]  Wolfgang Kreyling,et al.  The influence of improved air quality on mortality risks in Erfurt, Germany. , 2009, Research report.

[36]  A. Tobías,et al.  Case-Crossover Analysis of Air Pollution Health Effects: A Systematic Review of Methodology and Application , 2010, Environmental health perspectives.

[37]  Zhou Jin.  Study on the Association Between Ambient Air Quality and Daily Death in Beijing , 2003 .

[38]  Francesca Dominici,et al.  National maps of the effects of particulate matter on mortality: exploring geographical variation. , 2002, Environmental health perspectives.

[39]  J Sacks,et al.  Effect of outdoor airborne particulate matter on daily death counts. , 1995, Environmental health perspectives.