A comparison of mucosal inflammatory responses to Giardia muris in resistant B10 and susceptible BALB/c mice

In the first three weeks of primary Giardia muris infections B10 mice clear infection more rapidly than BALB/c mice. There is evidence that interferon‐γ contributes to the relative resistance of B10 mice. The nature of the functional contribution of interferon‐γ is unclear and does not relate to the secretory or serum antibody response. Mucosal inflammatory events in these strains have been studied. Apart from a small rise in both strains of goblet cell and mucosal mast cell numbers, associated with release of mast cell protease‐1 in serum, no inflammatory infiltrate was observed at the time trophozoites were cleared from the intestinal lumen. Inhibition of mast cell products (5‐hydroxytryptamine and histamine) by cyproheptadine enhanced the intensity of infection in both strains. The relative resistance of B10 mice could not be explained in terms of the mucosal inflammatory response.

[1]  D. Wakelin,et al.  Comparison of antibody and cytokine responses to primary Giardia muris infection in H-2 congenic strains of mice , 1996, Infection and immunity.

[2]  D. Wakelin,et al.  MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice. , 1993, International journal for parasitology.

[3]  Y. Horii,et al.  Immune-mediated alteration of the terminal sugars of goblet cell mucins in the small intestine of Nippostrongylus brasiliensis-infected rats. , 1993, Immunology.

[4]  K. Sliwa,et al.  Pentoxifylline prevents murine cerebral malaria. , 1991, The Journal of infectious diseases.

[5]  W. Seow,et al.  Inhibition of adherence of Giardia intestinalis by human neutrophils and monocytes. , 1991, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[6]  K. Chadee,et al.  The interaction between intestinal mucus glycoproteins and enteric infections. , 1991, Parasitology today.

[7]  K. Ovington,et al.  Oxygen derived free radicals and the course of Eimeria vermiformis infection in inbred strains of mice , 1990, Parasite immunology.

[8]  A. Buret,et al.  Effects of murine giardiasis on growth, intestinal morphology , and disaccharidase activity. , 1990, The Journal of parasitology.

[9]  D. Wakelin,et al.  Distribution of intestinal mast cell proteinase in blood and tissues of normal and Trichinella‐intected mice , 1990, Parasite immunology.

[10]  J. Gillon,et al.  Pathology and pathogenesis of the intestinal mucosal damage in giardiasis. , 1990 .

[11]  G. Visvesvara,et al.  Dietary fiber and giardiasis: dietary fiber reduces rate of intestinal infection by Giardia lamblia in the gerbil. , 1989, The American journal of tropical medicine and hygiene.

[12]  A. Ferguson,et al.  Giardia muris infection in mice with concurrent graft‐versus‐host reaction , 1988, Parasite immunology.

[13]  R. Crouch,et al.  Helminth anti-oxidant enzymes: a protective mechanism against host oxidants? , 1988, Parasitology today.

[14]  F. Gillin,et al.  Interactions of Giardia lamblia with human intestinal mucus: enhancement of trophozoite attachment to glass. , 1985, The Journal of protozoology.

[15]  M. McDermott,et al.  Chronic Giardia muris infection in anti-IgM-treated mice. I. Analysis of immunoglobulin and parasite-specific antibody in normal and immunoglobulin-deficient animals. , 1985, Journal of immunology.

[16]  J. Gillon.  Clinical Studies in Adults Presenting with Giardiasis to a Gastro-Intestinal Unit , 1985, Scottish medical journal.

[17]  B. Mannervik,et al.  4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase , 1985, FEBS letters.

[18]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.

[19]  R. Anders,et al.  An examination of differences in serum antibody specificities and hypersensitivity reactions as contributing factors to chronic infection with the intestinal protozoan parasite, Giardia muris, in mice. , 1983, The Australian journal of experimental biology and medical science.

[20]  S. Tannenbaum,et al.  Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. , 1982, Analytical biochemistry.

[21]  J. Gillon,et al.  Features of small intestinal pathology (epithelial cell kinetics, intraepithelial lymphocytes, disaccharidases) in a primary Giardia muris infection. , 1982, Gut.

[22]  E. Hewlett,et al.  Murine giardiasis: localization of trophozoites and small bowel histopathology during the course of infection. , 1982, The American journal of tropical medicine and hygiene.

[23]  J. Huntley,et al.  Immune exclusion and mucus trapping during the rapid expulsion of Nippostrongylus brasiliensis from primed rats. , 1981, Immunology.

[24]  D. Lindmark.  Energy metabolism of the anaerobic protozoon Giardia lamblia. , 1980, Molecular and biochemical parasitology.

[25]  A. Tomkins,et al.  Quantification of the lymphocytic infiltrate in jejunal epithelium in giardiasis. , 1977, Clinical and experimental immunology.

[26]  K. Warren,et al.  Suppression of giardiasis during the intestinal phase of trichinosis in the mouse. , 1976, Gut.

[27]  K. Warren,et al.  Giardiasis in the mouse: an animal model. , 1976, Gastroenterology.

[28]  T. Hendrix,et al.  EPITHELIAL AND OTHER MUCOSAL LESIONS OF THE JEJUNUM IN GIARDIASIS. JEJUNAL BIOPSY STUDIES. , 1964, Bulletin of the Johns Hopkins Hospital.