ADHD Discrimination Based on Social Network

Attention Deficit Hyperactivity Disorder (ADHD) is one of the common diseases of brain and has brought the growth of teenagers and even the adult indelible damage. It is very different to classify the ADHD symptoms and normal by the existing research. In this paper, the contributions are as two aspects: one is that the attributes of brain network of the resting state fMRI data have been calculated to discriminate three categories ADHD from the controls. And the average accuracies of various categories are 42.49% and 63.46% on the ADHD-200 datasets of NYU and KKI respectively, which is better than the average best imaging-based diagnostic performance of 35.19% and 61.90% achieved in the ADHD-200 global competition. The other one is that we put forward a new method named G-algorithm to construct the whole brain network, which based on certain rules. The same or even better classification results have been achieved by this method, which also verifies its feasibility and effectiveness.

[1]  Alfred Anwander,et al.  Neuroanatomical prerequisites for language functions in the maturing brain. , 2011, Cerebral cortex.

[2]  B. Biswal,et al.  Functional connectivity in the motor cortex of resting human brain using echo‐planar mri , 1995, Magnetic resonance in medicine.

[3]  J. Biederman,et al.  Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[4]  C. Stam,et al.  Small-world networks and disturbed functional connectivity in schizophrenia , 2006, Schizophrenia Research.

[5]  Mark E. J. Newman,et al.  The Structure and Function of Complex Networks , 2003, SIAM Rev..

[6]  I. M. Sokolov,et al.  Small-world Rouse networks as models of cross-linked polymers , 2000, cond-mat/0004392.

[7]  V. Haughton,et al.  Mapping functionally related regions of brain with functional connectivity MR imaging. , 2000, AJNR. American journal of neuroradiology.

[8]  Alan C. Evans,et al.  Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. , 2007, Cerebral cortex.

[9]  Edward T. Bullmore,et al.  Efficiency and Cost of Economical Brain Functional Networks , 2007, PLoS Comput. Biol..

[10]  Jan K Buitelaar,et al.  Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. , 2004, Journal of the American Academy of Child and Adolescent Psychiatry.

[11]  Gregory A. Miller,et al.  Classification of functional brain images with a spatio-temporal dissimilarity map , 2006, NeuroImage.

[12]  Hal Whitehead,et al.  Analyzing Animal Societies: Quantitative Methods for Vertebrate Social Analysis , 2008 .

[13]  T. Prescott,et al.  The brainstem reticular formation is a small-world, not scale-free, network , 2006, Proceedings of the Royal Society B: Biological Sciences.

[14]  B. Biswal,et al.  Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder , 2008, Biological Psychiatry.

[15]  C. Stam,et al.  Small-world networks and epilepsy: Graph theoretical analysis of intracerebrally recorded mesial temporal lobe seizures , 2007, Clinical Neurophysiology.

[16]  D. Cantwell Attention deficit disorder: a review of the past 10 years. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[17]  J N Giedd,et al.  Cerebellum in attention-deficit hyperactivity disorder , 1998, Neurology.

[18]  Klaas E. Stephan,et al.  The anatomical basis of functional localization in the cortex , 2002, Nature Reviews Neuroscience.

[19]  K. Amunts,et al.  Advances in cytoarchitectonic mapping of the human cerebral cortex. , 2001, Neuroimaging clinics of North America.

[20]  M. Newman,et al.  Random graphs with arbitrary degree distributions and their applications. , 2000, Physical review. E, Statistical, nonlinear, and soft matter physics.

[21]  Cornelis J Stam,et al.  Graph theoretical analysis of complex networks in the brain , 2007, Nonlinear biomedical physics.

[22]  Jordi Sabater-Mir,et al.  Reputation and social network analysis in multi-agent systems , 2002, AAMAS '02.

[23]  M E J Newman Assortative mixing in networks. , 2002, Physical review letters.

[24]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[25]  J. W. Campbell,et al.  Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655 , 2003, Journal of bacteriology.