Omega-3 supplementation can restore glutathione levels and prevent oxidative damage caused by prenatal ethanol exposure.

[1]  B. Christie,et al.  Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise , 2012, Neuropharmacology.

[2]  Jia Luo Mechanisms of Ethanol-Induced Death of Cerebellar Granule Cells , 2012, The Cerebellum.

[3]  B. Christie,et al.  The role of oxidative stress in fetal alcohol spectrum disorders , 2011, Brain Research Reviews.

[4]  B. Christie,et al.  Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome , 2011, Brain Research.

[5]  O. Vasieva The many faces of glutathione transferase pi. , 2011, Current molecular medicine.

[6]  B. Christie,et al.  Hippocampal cell loss and neurogenesis after fetal alcohol exposure: Insights from different rodent models , 2010, Brain Research Reviews.

[7]  F. J. Romero,et al.  Lutein and docosahexaenoic acid prevent cortex lipid peroxidation in streptozotocin-induced diabetic rat cerebral cortex , 2010, Neuroscience.

[8]  Tsuyoshi Miyakawa,et al.  Dissection of Hippocampal Dentate Gyrus from Adult Mouse , 2009, Journal of visualized experiments : JoVE.

[9]  Dar-Yu Yang,et al.  Protective effect of docosahexaenoic acid against brain injury in ischemic rats. , 2009, The Journal of nutritional biochemistry.

[10]  J. Fike,et al.  Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain , 2009, Journal of neuroscience research.

[11]  Hongqiao Zhang,et al.  Glutathione: overview of its protective roles, measurement, and biosynthesis. , 2009, Molecular aspects of medicine.

[12]  M. Druse,et al.  Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons , 2009, Brain Research.

[13]  E. Riley,et al.  Foetal Alcohol Spectrum Disorders and alterations in brain and behaviour. , 2009, Alcohol and alcoholism.

[14]  N. Bazan,et al.  Omega-3 fatty acids, the brain and retina. , 2008 .

[15]  F. Gomez-Pinilla,et al.  Brain foods: the effects of nutrients on brain function , 2008, Nature Reviews Neuroscience.

[16]  B. Halliwell,et al.  Biochemistry of oxidative stress. , 2007, Biochemical Society transactions.

[17]  X. Yao,et al.  Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[18]  Timothy H Murphy,et al.  Two-photon Imaging of Glutathione Levels in Intact Brain Indicates Enhanced Redox Buffering in Developing Neurons and Cells at the Cerebrospinal Fluid and Blood-Brain Interface* , 2006, Journal of Biological Chemistry.

[19]  I. Zararsız,et al.  Protective effects of ω‐3 essential fatty acids against formaldehyde‐induced neuronal damage in prefrontal cortex of rats , 2006 .

[20]  F. Calderon,et al.  Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation , 2006, Journal of neuroscience research.

[21]  Q. Pan,et al.  Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems , 2005, Brain Research.

[22]  C. Goodlett,et al.  Alcohol Teratogenesis: Mechanisms of Damage and Strategies for Intervention , 2005, Experimental biology and medicine.

[23]  Christopher J. Fox,et al.  Voluntary exercise rescues deficits in spatial memory and long‐term potentiation in prenatal ethanol‐exposed male rats , 2005, The European journal of neuroscience.

[24]  Meharban Singh Essential fatty acids, DHA and human brain , 2005, Indian journal of pediatrics.

[25]  Gerd Kempermann,et al.  Milestones of neuronal development in the adult hippocampus , 2004, Trends in Neurosciences.

[26]  M. Aksenov,et al.  Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus , 2004, International Journal of Developmental Neuroscience.

[27]  I. Zararsız,et al.  Hypothalamic superoxide dismutase, xanthine oxidase, nitric oxide, and malondialdehyde in rats fed with fish ω-3 fatty acids , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[28]  Hee-Yong Kim,et al.  Alterations in hippocampal phospholipid profile by prenatal exposure to ethanol , 2004, Journal of neurochemistry.

[29]  F. Fonnum,et al.  The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells , 2003, Journal of neurochemistry.

[30]  Xin Wang,et al.  Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures , 2003, Neuroreport.

[31]  R. Sokol,et al.  Fetal alcohol spectrum disorder. , 2003, JAMA.

[32]  S. Maffi,et al.  Ethanol‐induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons , 2003, Journal of neuroscience research.

[33]  A. Songur,et al.  Potential role of dietary omega-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatum. , 2003, Prostaglandins, leukotrienes, and essential fatty acids.

[34]  S. Sogut,et al.  The regulatory role of dietary ω-3 essential fatty acids on oxidant/antioxidant balance in rat hippocampus , 2003 .

[35]  D. B. Moore,et al.  The role of neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential temporal vulnerability of neonatal cerebellum to ethanol. , 2003, Alcoholism, clinical and experimental research.

[36]  D. B. Moore,et al.  Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum: relationship to periods of vulnerability. , 2003, Brain research. Developmental brain research.

[37]  M. Paiva,et al.  Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum , 2002, Neuroscience Letters.

[38]  J. Chen,et al.  In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal. , 2001, Alcoholism, clinical and experimental research.

[39]  R. Dringen,et al.  Metabolism and functions of glutathione in brain , 2000, Progress in Neurobiology.

[40]  P. Chan,et al.  Free radical pathways in CNS injury. , 2000, Journal of neurotrauma.

[41]  D. Rice,et al.  Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. , 2000, Environmental health perspectives.

[42]  E. Stadtman,et al.  Protein Oxidation , 2000, Annals of the New York Academy of Sciences.

[43]  C. Shaw,et al.  Glutathione and Signal Transduction in the Mammalian CNS , 1999, Journal of neurochemistry.

[44]  J. Chen,et al.  Ethanol, oxidative stress, reactive aldehydes, and the fetus. , 1999, Frontiers in bioscience : a journal and virtual library.

[45]  E. Reyes,et al.  Prevention by a silymarin/phospholipid compound of ethanol-induced social learning deficits in rats. , 1999, Planta medica.

[46]  D. Ortiz,et al.  Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. , 1999, Journal of ethnopharmacology.

[47]  L. Marnett Lipid peroxidation-DNA damage by malondialdehyde. , 1999, Mutation research.

[48]  M. Hossain,et al.  Antioxidative Effects of Docosahexaenoic Acid in the Cerebrum Versus Cerebellum and Brainstem of Aged Hypercholesterolemic Rats , 1999, Journal of neurochemistry.

[49]  W. Markesbery,et al.  Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity. , 1998, Free radical biology & medicine.

[50]  M. Hossain,et al.  Influence of docosahexaenoic acid on cerebral lipid peroxide level in aged rats with and without hypercholesterolemia , 1998, Neuroscience Letters.

[51]  A. Fantel,et al.  An introduction to reactive oxygen species and their possible roles in substance abuse. , 1998, Obstetrics and gynecology clinics of North America.

[52]  M. Duchen,et al.  Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system , 1997, Progress in Neurobiology.

[53]  R. Bronson,et al.  Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia* , 1997, The Journal of Biological Chemistry.

[54]  H. Sies,et al.  Oxidative stress: oxidants and antioxidants , 1997, Experimental physiology.

[55]  A. Postle,et al.  Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. , 1995, Biochimica et biophysica acta.

[56]  S. Schenker,et al.  In utero ethanol exposure elicits oxidative stress in the rat fetus. , 1995, Alcoholism, clinical and experimental research.

[57]  M. Philbert,et al.  Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells , 1995, Brain Research.

[58]  B. Robinson,et al.  Effects of in utero administration of alcohol on glutathione levels in brain and liver. , 1993, Alcoholism, clinical and experimental research.

[59]  V. Petkov,et al.  [Lipid peroxidation changes in the brain in fetal alcohol syndrome]. , 1992, Biulleten' eksperimental'noi biologii i meditsiny.

[60]  A. Meister,et al.  On the discovery of glutathione. , 1988, Trends in biochemical sciences.

[61]  J. Weinberg,et al.  Prenatal ethanol exposure: pituitary-adrenal activity in pregnant dams and offspring. , 1982, Neurobehavioral toxicology and teratology.

[62]  J. Altman,et al.  Prenatal development of the cerebellar system in the rat. I. Cytogenesis and histogenesis of the deep nuclei and the cortex of the cerebellum , 1978, The Journal of comparative neurology.

[63]  F. Tietze Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. , 1969, Analytical biochemistry.

[64]  A. Simopoulos Omega-3 fatty acids, the brain and retina. Preface. , 2009, World review of nutrition and dietetics.

[65]  David Buckley,et al.  Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. , 2009, Developmental disabilities research reviews.

[66]  M. Watabe,et al.  Regulation of neuronal glutathione synthesis. , 2008, Journal of pharmacological sciences.

[67]  R. Novak,et al.  Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system. , 1995, Neurotoxicology.

[68]  I. Carlberg,et al.  Glutathione reductase. , 1985, Methods in enzymology.

[69]  J. Weinberg,et al.  Effects of ethanol and maternal nutritional status on fetal development. , 1985, Alcoholism, clinical and experimental research.

[70]  B. Mannervik,et al.  [59] Glutathione reductase , 1985 .

[71]  A. Wendel Glutathione peroxidase. , 1981, Methods in enzymology.

[72]  W. Jakoby,et al.  Glutathione S-transferases (rat and human). , 1981, Methods in enzymology.

[73]  A. Wendel [44] Glutathione peroxidase , 1981 .

[74]  W. Jakoby,et al.  [27] Glutathione S-transferases (rat and human) , 1981 .

[75]  大川 博,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction , 1979 .