Xenotransplantation Literature Update May–June 2004

The efficiency of non-specific extracorporeal immunoadsorption, using polyclonal anti-human immunoglobulin antibodies, in depleting the serum of anti-Gal antibodies and in decreasing serum cytotoxicity to pig cells was studied in five patients with idiopathic dilated cardiomyopathy [3]. Extracoporeal immunoadsorption reduced serum concentration of anti-Gal IgM and IgG, and cytotoxicty to pig cells by 86, 88, and 73% respectively, with recovery by 1 month. Pigs transgenic for both human complement regulatory proteins CD55 and CD59 were engineered and double transgenic kidneys were transplanted into non-immunosuppressed baboons [4]. Transgenic kidneys did not develop hyperacute rejection and survived 5 and 6 days. Rejection was associated with coagulopathy, leukocyte infiltration and rebound of anti-Gal antibodies.

[1]  J. Platt,et al.  Xenotransplantation and the future of renal replacement. , 2005, The Journal of urology.

[2]  Meirigeng Qi,et al.  PVA hydrogel sheet macroencapsulation for the bioartificial pancreas. , 2004, Biomaterials.

[3]  B. Christ,et al.  Serum-free cryopreservation of porcine hepatocytes , 2004, Cell and Tissue Research.

[4]  R. Weiss,et al.  Reduced Sensitivity to Human Serum Inactivation of Enveloped Viruses Produced by Pig Cells Transgenic for Human CD55 or Deficient for the Galactosyl-α(1-3) Galactosyl Epitope , 2004, Journal of Virology.

[5]  B. Weill,et al.  Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. , 2004, Transplantation.

[6]  R. Lechler,et al.  DEVELOPING A PORCINE TRANSPLANTATION MODEL: EFFICIENT GENE TRANSFER INTO PORCINE VASCULAR CELLS , 2004, Transplantation.

[7]  R. Rieben,et al.  Lack of Galactose-α-1,3-Galactose Expression on Porcine Endothelial Cells Prevents Complement-Induced Lysis but Not Direct Xenogeneic NK Cytotoxicity1 , 2004, The Journal of Immunology.

[8]  D. Kaufman,et al.  Evidence that tilapia islets do not express α‐(1,3)gal: implications for islet xenotransplantation , 2004 .

[9]  E. Kitano,et al.  A study of the xenoantigenicity of adult pig islets cells , 2004, Xenotransplantation.

[10]  N. Mueller,et al.  Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation. , 2004, The Journal of infectious diseases.

[11]  C. Johnsson,et al.  The graft content of hyaluronan is increased during xenograft rejection , 2004, Xenotransplantation.

[12]  Akimasa Nakao,et al.  Are N‐glycolylneuraminic acid (Hanganutziu–Deicher) antigens important in pig‐to‐human xenotransplantation? , 2004, Xenotransplantation.

[13]  R. Hetzer,et al.  Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[14]  G. Dellgren,et al.  Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. , 2004, The Journal of thoracic and cardiovascular surgery.

[15]  R. Rieben,et al.  Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models , 2004, Xenotransplantation.

[16]  A. Mankertz,et al.  Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2 , 2004, Xenotransplantation.

[17]  J. Platt,et al.  Potential applications and prospects for cardiac xenotransplantation. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[18]  I. Goldstein,et al.  Comparison of the binding properties of the mushroom Marasmius oreades lectin and Griffonia simplicifolia I‐B4 isolectin to αgalactosyl carbohydrate antigens in the surface phase , 2004, Xenotransplantation.

[19]  M. Hammerman.  Renal organogenesis from transplanted metanephric primordia. , 2004, Journal of the American Society of Nephrology : JASN.

[20]  Bounleut Phanavanh,et al.  Sequence and mRNA expression of nonclassical SLA class I genes SLA-7 and SLA-8 , 2004, Immunogenetics.

[21]  O. Korsgren,et al.  IMPORTANCE OF THE GAL &agr;1–3 GAL ANTIGEN IN DISCORDANT ISLET XENOTRANSPLANTATION: IMMUNOSUPPRESSION, WHICH INHIBITS PORCINE ISLET XENOGRAFT REJECTION IN ORDINARY MICE, IS EQUALLY EFFECTIVE IN GAL-KNOCKOUT MICE , 2004, Transplantation.

[22]  D. Hess,et al.  Intracerebral Xenotransplantation of GFP Mouse Bone Marrow Stromal Cells in Intact and Stroke Rat Brain: Graft Survival and Immunologic Response , 2004, Cell transplantation.

[23]  M. Hammerman.  Organogenesis of kidneys following transplantation of renal progenitor cells. , 2004, Transplant immunology.

[24]  Hwan-You Chang,et al.  Establishing the Reactivity of Monoclonal Antibodies against Porcine Endogenous Retrovirus Envelope Protein , 2004, Intervirology.

[25]  William C Chapman,et al.  Natural Antibodies Prevent in Vivo Transmission of Porcine Islet-Derived Endogenous Retrovirus to Human Cells , 2004, Cell transplantation.

[26]  Paul D Griffiths,et al.  Susceptibility of porcine cytomegalovirus to antiviral drugs. , 2003, The Journal of antimicrobial chemotherapy.

[27]  D. Kaufman,et al.  Evidence that tilapia islets do not express alpha-(1,3)gal: implications for islet xenotransplantation. , 2004, Xenotransplantation.