Childhood tuberculosis in the European Union/European Economic Area, 2000 to 2009.

Childhood tuberculosis (TB) has been neglected for decades as a key component of TB control. However, ensuring proper monitoring of childhood TB has recently been given renewed emphasis. A descriptive analysis of surveillance data was performed to assess burden and trends of paediatric TB in the European Union/European Economic Area (EU/EEA) between 2000 and 2009. From 2000 to 2009, 39,695 notified paediatric (defined as 0–14 years of age) TB cases were reported by the 27 EU countries plus Norway, Iceland and Liechtenstein. These paediatric cases accounted for 4.3% of all notified cases. However, across the EU/EEA Member States, paediatric case notification rates ranged from 29.6 per 100,000 to 0.3 per 100,000 for the latest reporting year, 2009. Overall,though, these rates dropped from 5.5 per 100,000 in 2000 to 4.2 per 100,000 in 2009. The EU/EEA average annual percent changes (AAPC) in paediatric notification rates decreased between 2000 and 2004 by 1.3%and between 2005 and 2009 by 2.4%, with an overall decrease between 2000 and 2009 of 2.8%. Of all paediatric cases reported from 2000 to 2009, only 16.9%were culture-confirmed, amongst which the overall treatment success was 80.5% for all culture-confirmed pulmonary paediatric TB cases. Childhood TB in the EU/EEA remains a public health issue. Due attention should be paid to assessing paediatric trends as they could provide an insight in recent transmission. Whilst the primary aim of further reducing TB rates among children is paramount, better rates of appropriate diagnosis should also be achieved, along with a further improvement of therapeutic success rates.

[1]  T. Holtz,et al.  Epidemiology of tuberculosis among US- and foreign-born children and adolescents in the United States, 1994-2007. , 2010, American journal of public health.

[2]  M. D. de José,et al.  Impact of Immigration on Pulmonary Tuberculosis in Spanish Children: A Three-Decade Review , 2010, The Pediatric infectious disease journal.

[3]  B. Kampmann Impact of immigration on pulmonary tuberculosis in spanish children. , 2010, The Pediatric infectious disease journal.

[4]  A. Amato-Gauci,et al.  Analysis of tuberculosis treatment outcomes in the European Union and European Economic Area: efforts needed towards optimal case management and control. , 2010, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[5]  T. Mihăescu,et al.  Completeness of notification of adult tuberculosis in Iasi County, Romania: a capture-recapture analysis. , 2009, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[6]  A. Amato-Gauci,et al.  Tuberculosis in the EU and EEA/EFTA countries: what is the latest data telling us? , 2009, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[7]  D. Shingadia,et al.  Epidemiology and treatment outcome of childhood tuberculosis in England and Wales: 1999–2006 , 2008, Archives of Disease in Childhood.

[8]  T. Walls,et al.  The epidemiology of tuberculosis in Europe , 2007, Archives of Disease in Childhood.

[9]  A. Cruz,et al.  Clinical manifestations of tuberculosis in children. , 2007, Paediatric respiratory reviews.

[10]  L. Nelson,et al.  Global epidemiology of childhood tuberculosis. , 2004, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[11]  R. Gie,et al.  The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. , 2004, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[12]  A. Clarke,et al.  An evaluation of completeness of tuberculosis notification in the United Kingdom , 2003, BMC public health.

[13]  J Lees,et al.  European framework for tuberculosis control and elimination in countries with a low incidence , 2002, European Respiratory Journal.

[14]  P. Eamranond,et al.  Tuberculosis in children: reassessing the need for improved diagnosis in global control strategies. , 2001, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.