Numerical simulation and experimental study of resonance characteristics of QCM-P devices operating in liquid and their application in biological detection

Abstract Quartz Crystal Microbalance - micropillar (QCM-P) devices rely on system resonance between the QCM crystal and micropillars directly fabricated on its surface to obtain ultrahigh sensitivity. A numerical model was developed to study the effect of hydrodynamic loadings on a QCM-P device. The effect of substrates with inherent resonant frequencies of 5 and 10 MHz on device performance was also studied numerically. The QCM-P device showed different resonant frequency and amplitude while operated in air or water. As a demonstration of applications of QCM-P in biological detection, a 5 MHz QCM-P device was used to measure acrylic acid grafted on oxygen plasma treated poly(methyl methacrylate) (PMMA) micropillar surfaces. The QCM-P device produced a much higher frequency response than a conventional QCM sensor.

[1]  Quartz crystal microbalance with rigid mass partially attached on electrode surfaces , 2004 .

[2]  Vytautas Ostasevicius,et al.  Numerical analysis of fluid–structure interaction effects on vibrations of cantilever microstructure , 2007 .

[3]  G. McHale,et al.  Surface roughness and interfacial slip boundary condition for quartz crystal microbalances , 2004 .

[4]  Suresh V. Garimella,et al.  Hydrodynamic loading of microcantilevers vibrating in viscous fluids , 2006 .

[5]  Bongmun Kang,et al.  Efficient refolding and immobilization of PMMA-tag-fused single-chain Fv antibodies for sensitive immunological detection on a PMMA plate. , 2014, Journal of immunological methods.

[6]  Nico Karssemeijer,et al.  Ultrasonics, Ferroelectrics, and Frequency Control , 2011 .

[7]  A. Montazeri,et al.  Modeling and Eigenfrequency Analysis of Sound-Structure Interaction in a Rectangular Enclosure with Finite Element Method , 2009 .

[8]  Khalil Arshak,et al.  A review of gas sensors employed in electronic nose applications , 2004 .

[9]  Voravee P. Hoven,et al.  Synthesis and immobilization of thiolated pyrrolidinyl peptide nucleic acids on gold-coated piezoelectric quartz crystals for the detection of DNA hybridization , 2009 .

[10]  Jing Jin,et al.  Surface modification of poly (styrene-b-(ethylene-co-butylene)-b-styrene) elastomer and its plasma protein adsorption by QCM-D , 2014 .

[11]  M. Mozetič,et al.  Immobilization of protein streptavidin to the surface of PMMA polymer , 2012 .

[12]  X. Zhang,et al.  Quartz crystal microbalance study of the interfacial nanobubbles. , 2008, Physical chemistry chemical physics : PCCP.

[13]  Kimberly L. Turner,et al.  Frequency dependent fluid damping of micro/nano flexural resonators: Experiment, model and analysis , 2007 .

[14]  Stephen J. Martin,et al.  Effect of surface roughness on the response of thickness-shear mode resonators in liquids , 1993 .

[15]  Glen McHale,et al.  Acoustic wave-liquid interactions , 2000 .

[16]  George G. Guilbault,et al.  Commercial quartz crystal microbalances-Theory and applications , 1999 .

[17]  G. Sauerbrey.  Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .

[18]  M. Ward,et al.  In Situ Interfacial Mass Detection with Piezoelectric Transducers , 1990, Science.

[19]  R. Torresi,et al.  Lithium intercalation in nanostructured thin films of a mixed-valence layered vanadium oxide using an ionic liquid electrolyte , 2013 .

[20]  Fuqian Yang.  Effect of surface viscosity on the vibration of microcantilevers. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[21]  Cosimo Trono,et al.  An optical PMMA biochip based on fluorescence anisotropy: Application to C-reactive protein assay , 2009 .

[22]  Chih-Ming Ho,et al.  Surface molecular property modifications for poly(dimethylsiloxane) (PDMS) based microfluidic devices , 2009, Microfluidics and nanofluidics.

[23]  A. Aloisi,et al.  Quartz crystal microbalance with dissipation (QCM-D) as tool to exploit antigen-antibody interactions in pancreatic ductal adenocarcinomadetection. , 2013, Biosensors & bioelectronics.

[24]  Harold E. Hager,et al.  Velocity profile on quartz crystals oscillating in liquids , 1989 .

[25]  C. Leygraf,et al.  Combined in-situ investigations of atmospheric corrosion of copper with SFM and IRAS coupled with QCM , 2000 .

[26]  Der Ho Wu,et al.  Robust design of quartz crystal microbalance using finite element and Taguchi method , 2003 .

[27]  Antonio Arnau,et al.  A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids , 2008, Sensors.

[28]  D. Haddleton,et al.  An investigation into thiol–ene surface chemistry of poly(ethylene glycol) acrylates, methacrylates and CCTP polymers via quartz crystal microbalance with dissipation monitoring (QCM-D) , 2012 .

[29]  Hongwei Sun,et al.  An ultrasensitive quartz crystal microbalance-micropillars based sensor for humidity detection , 2014 .

[30]  S. Cosnier,et al.  High sensitive trypsin activity evaluation applying a nanostructured QCM-sensor. , 2013, Biosensors & bioelectronics.

[31]  J. H. Lee,et al.  Immobilization of proteins on poly(methyl methacrylate) films. , 1993, Biomaterials.

[32]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .

[33]  J. Gordon,et al.  Frequency of a quartz microbalance in contact with liquid , 1985 .

[34]  J. Bin,et al.  Fluid–structure interactions of photo-responsive polymer cantilevers , 2013 .

[35]  E. Lojou,et al.  Key role of the anchoring PEI layer on the electrochemistry of redox proteins at carbon electrodes: Consequences on assemblies involving proteins and clay , 2007 .

[36]  Weiling Fu,et al.  Rapid parallelized and quantitative analysis of five pathogenic bacteria by ITS hybridization using QCM biosensor , 2011 .

[37]  Matthew A Cooper,et al.  A Survey of the 2010 Quartz Crystal Microbalance Literature , 2012, Journal of molecular recognition : JMR.

[38]  Pengtao Wang,et al.  Ultrasensitive quartz crystal microbalance enabled by micropillar structure , 2014 .

[39]  K. Kallury,et al.  Mediation of acoustic energy transmission from acoustic wave sensors to the liquid phase by interfacial viscosity , 1991 .

[40]  Robert Q Frazer,et al.  PMMA: an essential material in medicine and dentistry. , 2005, Journal of long-term effects of medical implants.

[41]  Biljana A. Čavić-Vlasak,et al.  Application potential of liquid-phase acoustic wave devices as chemical and biochemical sensors , 1992 .

[42]  W. H. King.  Piezoelectric Sorption Detector. , 1964 .

[43]  B. Gupta,et al.  Plasma-induced graft polymerization of acrylic acid onto poly(ethylene terephthalate) films: characterization and human smooth muscle cell growth on grafted films. , 2001, Biomaterials.

[44]  B. Gupta,et al.  Plasma-induced graft polymerization of acrylic acid onto poly(ethylene terephthalate) films: characterization and human smooth muscle cell growth on grafted films. , 2001, Biomaterials.

[45]  M. Barboiu,et al.  Atmospheric pressure plasma polymers for tuned QCM detection of protein adhesion. , 2014, Biosensors & bioelectronics.

[46]  Michael Multerer,et al.  Rapid impedance scanning QCM for electrochemical applications based on miniaturized hardware and high-performance curve fitting , 2008 .

[47]  Yi‐Pin Chang,et al.  Biomolecular interactions and tools for their recognition: focus on the quartz crystal microbalance and its diverse surface chemistries and applications. , 2012, Chemical Society reviews.