Neurofollicular Hamartoma: A Clinicopathological Study

We review two patients with unusual pilosebaceous and spindle cell neoplasms. Both lesions were on the nose and were clinically similar to angiofibroma. Immunoperoxidase (S-100 protein, vimentin, immunostain for actin) and special stains (Masson's trichrome, periodic acid-Schiff. and Bielschowsky silver stain) were used to evaluate the lesions. The histologic differential diagnosis included neural nevi, trichogenic myxoma, trichodiscoma, benign neural and vascular tumors, and dermal scar formation. Our patients, we believe, had single asymptomatic smooth, skin-colored papules; this condition was recently termed “neurofollicular hamartoma.”