The Hippocampal‐Dentate Complex in Temporal Lobe Epilepsy

The hippocampal‐dentate complex of 11 patients operated for temporal lobe epilepsy was studied by variations of the Golgi method. A spectrum of changes in hippocampal pyramids and dentate granular cells was found, ranging from minor pathology along single dendrites to massive degenerative changes involving many neurons, and culminating in cell death. Loss of dendritic spines and development of nodules along dendritic shafts were the mildest pathological changes. That pathology could be highly localized and could vary in degree in the same patient suggests an ongoing process rather than one due to discrete cortical insult in early life.

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