THE MEDIATION OF MACROPHAGE REACTION IN INFLAMMATION, WITH SPECIAL REFERENCE TO IgG‐DERIVED CHEMOTACTIC FACTOR

Three different macrophage chemotactic factors were separated from hypersensitivity skin lesions induced by DNP‐ascaris extract or PPD. The amount of each factor seemed to be changeable according to the nature of inflammatory stimuli. The chemotactic activity of the factor a was completely absorbed by anti‐IgG and anti‐light chain antibodies, while that of the factors b and c was not absorbed by the antibodies. The factor a was produced from IgG by neutrophil neutral serine protease resembling elastase but fatling to digest elastin‐orcein; its chemotactic generation was accompanied by release of dialysable peptide(s) from the IgG molecule, suggesting a minor structural change of the IgG molecule. Production of leucoegresin or lymphocyte chemotactic factor by europhile neutral thiol protease from IgG molecule was discussed.

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