Imedeen®, a new compound for oral administration consisting of special protein fractions and some glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39 – 61 years, were treated with 0.5 g/day Imedeen® for 90 days. At baseline and after 30, 60 and 90 days, the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and brittleness of hair and nails was normalized in all cases. These clinical observations were confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen® or placebo for 90 days. The results in the Imedeen®-treated group corresponded to those in the first study whereas no response to treatment was observed in the placebo treatment group.
[1]
H. Bouissou,et al.
Age dependent biochemical changes in dermal connective tissue. Relationship to histological and ultrastructural observations.
,
1980,
Connective tissue research.
[2]
D A Parry,et al.
A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties
,
1978,
Proceedings of the Royal Society of London. Series B. Biological Sciences.
[3]
E. Davidson,et al.
Alterations in human dermal connective tissue with age and chronic sun damage.
,
1962,
The Journal of investigative dermatology.
[4]
F. O. Schmitt,et al.
THE STRUCTURE OF HUMAN SKIN COLLAGEN AS STUDIED WITH THE ELECTRON MICROSCOPE
,
1948,
The Journal of experimental medicine.