论文信息 - Compact, low-cost Ti:Al2O3 laser for in vivo ultrahigh-resolution optical coherence tomography.

Compact, low-cost Ti:Al2O3 laser for in vivo ultrahigh-resolution optical coherence tomography.

A compact, low-cost, prismless Ti:Al2O3 laser with 176-nm bandwidth (FWHM) and 20-mW output power was developed. Ultrahigh-resolution ophthalmic optical coherence tomography (OCT) ex vivo imaging in an animal model with approximately 1.2-microm axial resolution and in vivo imaging in patients with macular pathologies with approximately 3-microm axial resolution were demonstrated. Owing to the pump laser, this light source significantly reduces the cost of broadband OCT systems. Furthermore, the source has great potential for clinical application of spectroscopic and ultrahigh-resolution OCT because of its small footprint (500 mm x 180 mm including the pump laser), user friendliness, stability, and reproducibility.

[1] U. Morgner,et al. Generation of sub-10-fs pulses from a Kerr-lens mode-locked Cr(3+):LiCAF laser oscillator by use of third-order dispersion-compensating double-chirped mirrors. , 2002, Optics letters.

[2] J. Fujimoto,et al. Spectroscopic optical coherence tomography. , 2000 .

[3] K. Torizuka,et al. Generation of 10 fs Pulses from a Diode-Pumped Kerr-Lens Mode-Locked Cr:LiSAF Laser , 1999, Optics letters.

[4] A. Fercher,et al. Submicrometer axial resolution optical coherence tomography. , 2002, Optics letters.

[5] J G Fujimoto,et al. Ultralow-threshold Kerr-lens mode-locked Ti:Al(2)O(3) laser. , 2002, Optics letters.

[6] Adolf Friedrich Fercher. Optical coherence tomography. , 1996 .

[7] J. Fujimoto,et al. Optical Coherence Tomography , 1991 .

[8] R. Szipöcs,et al. 14-fs pulse generation in Kerr-lens mode-locked prismless Cr:LiSGaF and Cr:LiSAF lasers: observation of pulse self-frequency shift. , 1997, Optics letters.

[9] J. Fujimoto,et al. In vivo ultrahigh-resolution optical coherence tomography. , 1999, Optics letters.