Pharmacokinetics for anaesthesia

Part 1 Basic essentials: a mathematical toolbox molecules in action passage of drugs across membranes some basic pharmacokinetic concepts. Part 2 What happens to drugs in the body: drug uptake and availability drug distribution the dynamic of drug action metabolism and excretion of drugs variation in drug disposition II - pregnancy, disease, drugs and anaesthetesia. Part 3 Pharmacokinetic analysis: the measurement of drug concentrations in body fluids the one compartment open model models with more than one compartment the identification of compartmental models physiological models some more advanced ideas. Part 4 Pharmacokinetics of some drugs used in anaesthesia: inhalational anaesthetic agents intravenous anaesthetic agents opioids neuromuscular blocking agents. Part 5 Putting pharmacokinetics to work: a toolbox for compartmental models dosing strategies and control. Appendices: estimation of the area under a concentration-time curve computer program - PROJECT.