Nonlinearity in giant depolarizing potentials

Synchronous population discharges in immature neurons, or giant depolarizing potentials (GDPs), are considered to have an important role in the development of the functional network in hippocampus and other neural tissue before or briefly after birth. Recently, theoretical models have emphasized the possible role of chaotic, nonlinear activity at circuit level in establishing functional connectivity in neural tissue. Combining these two hypotheses leads to the prediction that GDPs have chaotic characteristics. We tested nonlinearity in GDPs recorded from transverse hippocampal slices of neonatal Wistar rats. Our results provide evidence of nonlinearity in GDP activity at circuit level.

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