Femtosecond lentotomy: generating gliding planes inside the crystalline lens to regain accommodation ability

Based on Helmholtz Theory for accommodation the increasing sclerosis of lens nucleus and cortex is the main cause for the developments of presbyopia. Existing therapies, however, do not reverse the stiffness of the crystalline lens and thus do not regain real accommodation ability. A new approach to restore the flexibility of the lens could be realized by photodisruption using ultrafast laser pulses. This process, known as fs-lentotomy, was used to create micro-incisions which act as gliding planes inside the crystalline lens without opening the eye globe.

[1]  Holger Lubatschowski,et al.  Femtosecond laser induced flexibility change of human donor lenses , 2009, Vision Research.

[2]  H. Welling,et al.  Application of ultrashort laser pulses for intrastromal refractive surgery , 2000, Graefe's Archive for Clinical and Experimental Ophthalmology.

[3]  Burghard Lipphardt,et al.  Kerr-lens, mode-locked lasers as transfer oscillators for optical frequency measurements , 2002 .

[4]  Perry S. Binder,et al.  One thousand consecutive IntraLase laser in situ keratomileusis flaps , 2006, Journal of cataract and refractive surgery.

[5]  T. Rabsilber,et al.  Penetrating keratoplasty using femtosecond laser. , 2007, American journal of ophthalmology.

[6]  Achim Langenbucher,et al.  Nonmechanical posterior lamellar keratoplasty using the femtosecond laser (femto-plak) for corneal endothelial decompensation. , 2003, American journal of ophthalmology.

[7]  Holger Lubatschowski,et al.  Nonlinear side effects of fs pulses inside corneal tissue during photodisruption , 2002 .

[8]  K. Stonecipher,et al.  Advances in refractive surgery: microkeratome and femtosecond laser flap creation in relation to safety, efficacy, predictability, and biomechanical stability , 2006, Current opinion in ophthalmology.

[9]  A. Vogel,et al.  Mechanisms of femtosecond laser nanosurgery of cells and tissues , 2005 .

[10]  R R Krueger,et al.  Experimental increase in accommodative potential after neodymium: yttrium-aluminum-garnet laser photodisruption of paired cadaver lenses. , 2001, Ophthalmology.

[11]  R R Krueger,et al.  Novel approaches to correction of presbyopia with laser modification of the crystalline lens. , 1998, Journal of refractive surgery.