Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

Poly(styrene‐co‐divinylbenzene)‐coated magnetic multiwalled carbon nanotube composite synthesized by in‐situ high temperature combination and precipitation polymerization of styrene‐co‐divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary electrophoresis with diode array detection. The presence of magnetic multiwalled carbon nanotubes in native poly(styrene‐co‐divinylbenzene) not only simplified sample treatment but also enhanced the adsorption efficiencies, obtaining extraction recoveries higher than 89.5% for all analytes. Moreover, this composite can be re‐used at least ten times without loss of efficiency and limits of detection ranging from 0.014 to 0.041 μg/mL were calculated. Additionally, precision values ranging from 0.08 to 7.50% and from 0.21 to 3.05% were obtained for the responses and for the migration times of the analytes, respectively.

[1]  H. Sternbach.  The serotonin syndrome. , 1991, The American journal of psychiatry.

[2]  L. Labat,et al.  Separation of new antidepressants and their metabolites by micellar electrokinetic capillary chromatography. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3]  M. Riekkola,et al.  Capillary zone electrophoresis of basic analytes in methanol as non-aqueous solvent mobility and ionisation constant. , 2001, Journal of chromatography. A.

[4]  Y. Yamini,et al.  Combination of electromembrane extraction with dispersive liquid-liquid microextraction followed by gas chromatographic analysis as a fast and sensitive technique for determination of tricyclic antidepressants. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[5]  A. M. Salcedo,et al.  Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC , 2009, Electrophoresis.

[6]  S. Shim,et al.  Effect of the polymerization parameters on the morphology and spherical particle size of poly(styrene-co-divinylbenzene) prepared by precipitation polymerization , 2004 .

[7]  D. Gourion,et al.  [Antidepressant and tolerance: Determinants and management of major side effects]. , 2016, L'Encephale.

[8]  Á. Ríos,et al.  Magnetic molecular imprint-based extraction of sulfonylurea herbicides and their determination by capillary liquid chromatography , 2013, Microchimica Acta.

[9]  Á. Ríos,et al.  Magnetic (nano)materials as an useful tool for sample preparation in analytical methods. A review , 2013 .

[10]  S. Carda‐Broch,et al.  Determination of selective serotonin reuptake inhibitors in plasma and urine by micellar liquid chromatography coupled to fluorescence detection. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  M. Amore,et al.  Determination of duloxetine in human plasma by capillary electrophoresis with laser-induced fluorescence detection. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[12]  R. Das,et al.  Simultaneous monitoring of selective serotonin reuptake inhibitors in human urine, plasma and oral fluid by reverse-phase high performance liquid chromatography. , 2013, Journal of chromatographic science.

[13]  A. Gómez-Caballero,et al.  Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography. , 2008, Journal of pharmaceutical and biomedical analysis.

[14]  A. Gómez-Caballero,et al.  Development of a stir bar sorptive extraction based HPLC-FLD method for the quantification of serotonin reuptake inhibitors in plasma, urine and brain tissue samples. , 2010, Journal of pharmaceutical and biomedical analysis.

[15]  C. Gagnon,et al.  Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment--evidence of biological effects. , 2011, Chemosphere.

[16]  Nora Unceta,et al.  Analytical procedures for the determination of the selective serotonin reuptake inhibitor antidepressant citalopram and its metabolites. , 2011, Biomedical chromatography : BMC.

[17]  A. Llerena,et al.  Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers , 2014, Drug metabolism and drug interactions.

[18]  Angel Ríos,et al.  Hybrid nanoparticles based on magnetic multiwalled carbon nanotube-nanoC18SiO2 composites for solid phase extraction of mycotoxins prior to their determination by LC-MS , 2016, Microchimica Acta.

[19]  R. Ito,et al.  Improvement and validation the method using dispersive liquid-liquid microextraction with in situ derivatization followed by gas chromatography-mass spectrometry for determination of tricyclic antidepressants in human urine samples. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[20]  Laura Gámiz-Gracia,et al.  Chemiluminescence detection in liquid chromatography: applications to clinical, pharmaceutical, environmental and food analysis--a review. , 2009, Analytica chimica acta.

[21]  J. Nevado,et al.  Development and validation method for determination of fluoxetine and its main metabolite norfluoxetine by nonaqueous capillary electrophoresis in human urine. , 2005, Talanta.

[22]  H. Choi,et al.  Fully crosslinked poly(styrene‐co‐divinylbenzene) microspheres by precipitation polymerization and their superior thermal properties , 2004 .

[23]  S. Machado,et al.  Electrochemical sensor based on reduced graphene oxide modified with palladium nanoparticles for determination of desipramine in urine samples , 2017 .

[24]  Mohammad Mirzaei,et al.  Sensitive spectrophotometric determination of fluoxetine from urine samples using charge transfer complex formation after solid phase extraction by magnetic multiwalled carbon nanotubes , 2014 .

[25]  Nobhojit Roy,et al.  Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition , 2015, The Lancet.

[26]  J. Petersen,et al.  Clinical and Forensic Applications of Capillary Electrophoresis , 2001, Pathology and Laboratory Medicine.

[27]  Yuqi Feng,et al.  In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma. , 2010, Journal of chromatography. A.

[28]  N. W. Barnett,et al.  Capillary electrophoresis for forensic drug analysis: A review. , 2005, Talanta.

[29]  M. Valcárcel,et al.  Fast urinary screening for imipramine and desipramine using on-line solid-phase extraction and selective derivatization. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[30]  Q. Fu,et al.  Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres , 2012 .

[31]  Miguel Valcárcel,et al.  Combined use of carbon nanotubes and ionic liquid to improve the determination of antidepressants in urine samples by liquid chromatography , 2008, Analytical and bioanalytical chemistry.

[32]  C. Gagnon,et al.  Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada. , 2012, Water research.

[33]  Antonio V. Herrera-Herrera,et al.  Carbon nanotubes: Solid-phase extraction. , 2010, Journal of chromatography. A.

[34]  W. Lambert,et al.  Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. , 2005, Journal of chromatography. A.

[35]  Eric R. Ziegel,et al.  Statistics and Chemometrics for Analytical Chemistry , 2004, Technometrics.

[36]  F. Tagliaro,et al.  Capillary Electrophoresis in Forensic Chemistry , 2013 .