A Rare Case of Sinonasal Extramedullary Plasmacytoma with Orbital Involvement

Extramedullary plasmacytoma (EMP) is a rare entity in the head and neck region. It is phenotypically and immunologically diffe rent from multiple myeloma. Chronic transformation to multiple myeloma or its disseminated form is well known. It may even be the first manifestation of multiple myeloma also popularly known as secondary EMP. We present a 43-year-old male patient with history of persistent progressive nasal obstruction with occasional epistaxis. Endoscopy revealed a right sinonasal mass which on excision biopsy was consistent with features of EMP. Extramedullary plasmacytoma is a rare differential diagnosis for sinonasal mass. However, multiple myeloma should be ruled out via bone marrow examination, bone scan and serum and urine electrophoretic evaluation before arising at a diagnosis of EMP. In spite of EMP of nasal cavity being a rare entity, it should be considered as one of the rare differential diagnoses.