Mirror neuron system involvement in empathy: A critical look at the evidence

It has been proposed that the human mirror neuron system (MNS) plays an integral role in mediating empathy. In this review, we critically examine evidence from three bodies of research that have been cited as supporting this notion: (1) behavioral studies that have examined the relationship between imitation and empathy, (2) findings from functional neuroimaging studies that report a positive correlation between MNS activation and self-report on an empathy questionnaire, and (3) observations of impaired imitation and empathy in autism spectrum disorders (ASD). In addition, we briefly review lesion studies of the neural correlates of imitation and empathy. Current evidence suggests that the MNS is broadly involved in empathy, but at this stage there has been limited consideration of its various forms, including motor, emotional, and cognitive empathy. There are also various forms of imitation, encompassing emotional and non-emotional, automatic, and voluntary actions. We propose that the relationship between imitation and empathy may vary depending on the specific type of each of these abilities. Furthermore, these abilities may be mediated by partially distinct neural networks, which involve the MNS to a variable degree.

[1]  H. Pashler,et al.  Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition 1 , 2009, Perspectives on psychological science : a journal of the Association for Psychological Science.

[2]  Gregory Hickok,et al.  Eight Problems for the Mirror Neuron Theory of Action Understanding in Monkeys and Humans , 2009, Journal of Cognitive Neuroscience.

[3]  P. Winkielman,et al.  When the social mirror breaks: deficits in automatic, but not voluntary, mimicry of emotional facial expressions in autism. , 2006, Developmental science.

[4]  T. Chartrand,et al.  The chameleon effect: the perception-behavior link and social interaction. , 1999, Journal of personality and social psychology.

[5]  Oliver T Wolf,et al.  Dissociation of Cognitive and Emotional Empathy in Adults with Asperger Syndrome Using the Multifaceted Empathy Test (MET) , 2008, Journal of autism and developmental disorders.

[6]  A. Whiten,et al.  A Systematic Review of Action Imitation in Autistic Spectrum Disorder , 2004, Journal of autism and developmental disorders.

[7]  Jean Decety,et al.  Unconscious affective processing and empathy: An investigation of subliminal priming on the detection of painful facial expressions , 2009, Pain.

[8]  C. Tardif,et al.  Author manuscript, published in "Journal of Autism and Developmental Disorders (2007) 1469-1484" 1 , 2008 .

[9]  Jean Decety,et al.  Neurodevelopmental changes in the circuits underlying empathy and sympathy from childhood to adulthood. , 2010, Developmental science.

[10]  J. Mazziotta,et al.  Mirror neuron system: basic findings and clinical applications , 2007, Annals of neurology.

[11]  J. Decety.  To What Extent is the Experience of Empathy Mediated by Shared Neural Circuits? , 2010 .

[12]  R. Blair.  Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations , 2005, Consciousness and Cognition.

[13]  R. Goebel,et al.  The brain's intention to imitate: The neurobiology of intentional versus automatic imitation , 2008, Brain Stimulation.

[14]  G. Rizzolatti,et al.  Both of Us Disgusted in My Insula The Common Neural Basis of Seeing and Feeling Disgust , 2003, Neuron.

[15]  T. Singer,et al.  The empathic brain: how, when and why? , 2006, Trends in Cognitive Sciences.

[16]  J. Aharon-Peretz,et al.  Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. , 2009, Brain : a journal of neurology.

[17]  R. Blair.  Fine Cuts of Empathy and the Amygdala: Dissociable Deficits in Psychopathy and Autism , 2008, Quarterly journal of experimental psychology.

[18]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[19]  M. Iacoboni.  Imitation, empathy, and mirror neurons. , 2009, Annual review of psychology.

[20]  John C. Mazziotta,et al.  Mirroring others' emotions relates to empathy and interpersonal competence in children , 2008, NeuroImage.

[21]  C. Keysers,et al.  Empathy and the Somatotopic Auditory Mirror System in Humans , 2006, Current Biology.

[22]  C. Montag,et al.  Theodor Lipps and the concept of empathy: 1851-1914. , 2008, The American journal of psychiatry.

[23]  J Aharon-Peretz,et al.  Empathy Deficits in Asperger Syndrome: a Cognitive Profile , 2002, Neurocase.

[24]  Mark H. Davis.  Measuring individual differences in empathy: Evidence for a multidimensional approach. , 1983 .

[25]  J. Mattingley,et al.  Is the mirror neuron system involved in imitation? A short review and meta-analysis , 2009, Neuroscience & Biobehavioral Reviews.

[26]  J. Decety,et al.  To what extent do we share the pain of others? Insight from the neural bases of pain empathy , 2006, Pain.

[27]  Jan Derrfuss,et al.  Imitative response tendencies in patients with frontal brain lesions. , 2003, Neuropsychology.

[28]  C. Gillberg,et al.  The Emanuel Miller Memorial Lecture 1991. Autism and autistic-like conditions: subclasses among disorders of empathy. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[29]  S. Preston,et al.  Empathy: Its ultimate and proximate bases. , 2001, The Behavioral and brain sciences.

[30]  A. Mehrabian,et al.  A measure of emotional empathy. , 1972, Journal of personality.

[31]  S. Baron-Cohen,et al.  The Empathy Quotient: An Investigation of Adults with Asperger Syndrome or High Functioning Autism, and Normal Sex Differences , 2004, Journal of autism and developmental disorders.

[32]  Á. Pascual-Leone,et al.  Psychopathy and the mirror neuron system: Preliminary findings from a non-psychiatric sample , 2008, Psychiatry Research.

[33]  J. Mazziotta,et al.  Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Gaspare Galati,et al.  Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain , 2005, Nature Neuroscience.

[35]  R. Hari,et al.  Abnormal imitation‐related cortical activation sequences in Asperger's syndrome , 2004, Annals of neurology.

[36]  Scott T Grafton,et al.  Functional imaging of face and hand imitation: towards a motor theory of empathy , 2004, NeuroImage.

[37]  V. Gallese.  The Roots of Empathy: The Shared Manifold Hypothesis and the Neural Basis of Intersubjectivity , 2003, Psychopathology.

[38]  Christian Keysers,et al.  Empathy for positive and negative emotions in the gustatory cortex , 2007, NeuroImage.

[39]  Oliver T Wolf,et al.  Who Cares? Revisiting Empathy in Asperger Syndrome , 2007, Journal of autism and developmental disorders.

[40]  R. Cabeza,et al.  Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies , 2000, Journal of Cognitive Neuroscience.

[41]  C. Heyes,et al.  Intact automatic imitation of human and robot actions in autism spectrum disorders , 2007, Proceedings of the Royal Society B: Biological Sciences.

[42]  Paul J. Eslinger,et al.  Neurological and Neuropsychological Bases of Empathy , 1998, European Neurology.

[43]  T. Yarkoni.  Big Correlations in Little Studies: Inflated fMRI Correlations Reflect Low Statistical Power—Commentary on Vul et al. (2009) , 2009, Perspectives on psychological science : a journal of the Association for Psychological Science.

[44]  H. Freund,et al.  Recognition and imitation of pantomimed motor acts after unilateral parietal and premotor lesions: a perspective on apraxia , 2001, Neuropsychologia.

[45]  Jennifer H. Pfeifer,et al.  Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders , 2006, Nature Neuroscience.

[46]  D. Perrett,et al.  Imitation, mirror neurons and autism , 2001, Neuroscience & Biobehavioral Reviews.

[47]  A. Hamilton,et al.  Imitation and action understanding in autistic spectrum disorders: How valid is the hypothesis of a deficit in the mirror neuron system? , 2007, Neuropsychologia.

[48]  M. Iacoboni,et al.  Getting a grip on other minds: Mirror neurons, intention understanding, and cognitive empathy , 2006, Social Neuroscience.

[49]  S. Provence,et al.  Form Perception and Imitation in Some Autistic Children: Diagnostic Findings and Their Contextual Interpretation , 1953 .

[50]  Dennis C. Tkach,et al.  Congruent Activity during Action and Action Observation in Motor Cortex , 2007, The Journal of Neuroscience.

[51]  M. Sonnby-Borgström.  Automatic mimicry reactions as related to differences in emotional empathy. , 2002, Scandinavian journal of psychology.

[52]  D. Perrett,et al.  Neural mechanisms of imitation and ‘mirror neuron’ functioning in autistic spectrum disorder , 2006, Neuropsychologia.