Design, implementation, and characterization of spectrometer-based spectral domain optical coherence tomography

We report the implementation of a high speed and high resolution spectrometer-based spectral domain optical coherence tomography (SD-OCT) system. A high speed near-infrared spectrometer was designed and built, utilizing a high speed line-array CMOS detector and all off-the-shelf optical components. The acquisition speed of more than 100,000 spectra per second was achieved, enabling a high speed 3D imaging of the implemented SD-OCT system. Here, we report the performance characterization, i.e. resolution, imaging depth, and sensitivity of the implemented system. The penetration depth and depth resolution of the system are currently 2 mm and 14.1 μm, respectively. The lateral resolution of the system was quantified by the Modulation transfer function (MTF) measurement to be about 15.5 μm. over the lateral field-of-view (x-y axes) of 30 mm × 30 mm. The acquisition speed of the system was 20 frames per second.

[1]  E. Wolf,et al.  Principles of Optics (7th Ed) , 1999 .

[2]  Panomsak Meemon,et al.  Cellular resolution optical coherence microscopy with high acquisition speed for in-vivo human skin volumetric imaging. , 2011, Optics letters.

[3]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[4]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[5]  Panomsak Meemon,et al.  Gabor-based fusion technique for Optical Coherence Microscopy. , 2010, Optics express.

[6]  Jannick P. Rolland,et al.  Swept-source based, single-shot, multi-detectable velocity range Doppler optical coherence tomography , 2010, Biomedical optics express.

[7]  Wolfgang Drexler,et al.  State-of-the-art retinal optical coherence tomography , 2008, Progress in Retinal and Eye Research.

[8]  B. Bouma,et al.  Handbook of Optical Coherence Tomography , 2001 .

[9]  Maciej Wojtkowski,et al.  High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. , 2006, Ophthalmology.

[10]  M. Brezinski.  Optical Coherence Tomography: Principles and Applications , 2006 .

[11]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[12]  David Huang,et al.  Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography. , 2009, Optics express.

[13]  Jannick P. Rolland,et al.  Determination of the coherency matrix of a broadband stochastic electromagnetic light beam , 2008 .

[14]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[15]  Jannick P. Rolland,et al.  Doppler imaging with dual-detection full-range frequency domain optical coherence tomography , 2010, Biomedical optics express.

[16]  A. Fercher,et al.  Optical coherence tomography - principles and applications , 2003 .