Design and optimization in organic synthesis

1. Introduction: Strategies on different levels in organic synthesis. 2. Experimental study of reaction conditions. Initial remarks. 3. Models as tools. 4. General outline for screening experiments. 5. Two-level factorial designs. 6. Two-level fractional factorial design. 7. Other designs for screening experiments. 8. Summary of screening experiments. 9. Introduction to optimization. 10. Steepest ascent. 11. Simplex methods. 12. Response surface methods. 13. Summary of strategies to explore the experimental space. 14. The reaction space. 15. Principal properties. 16. Strategies for the selection of test systems. 17. Quantitative relations between observed responses and experimental variations. 18. A method for determining a suitable order of introducing reagents in "one-pot" procedures. 19. Concluding remarks. Appendices. Index.