The dendritic spine story: an intriguing process of discovery

Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study of the nervous system, and will also explore the early interpretation of these elements. This discovery represents an interesting chapter in the history of neuroscience as it shows us that progress in the study of the structure of the nervous system is based not only on the emergence of new techniques but also on our ability to exploit the methods already available and correctly interpret their microscopic images.

[1]  Andrea Klug,et al.  The Hippocampus Book , 2016 .

[2]  Antonio Núñez Rodríguez.  Recuerdos de mi vida , 2014 .

[3]  P. Ehrlich.  Über das Methylenblau und seine klinisch-bakterioskopische Verwerthung* , 2013 .

[4]  J. DeFelipe,et al.  Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[5]  K. Jellinger.  Cajal’s Butterflies of the Soul: Science and Art , 2010 .

[6]  S. Hatai,et al.  The Finer Structure of the Neurones in the Nervous System of the White Rat , 2009 .

[7]  J. DeFelipe,et al.  Gender differences in human cortical synaptic density , 2008, Proceedings of the National Academy of Sciences.

[8]  R. Yuste,et al.  Non-synaptic dendritic spines in neocortex , 2007, Neuroscience.

[9]  Javier DeFelipe,et al.  Brain plasticity and mental processes: Cajal again , 2006, Nature Reviews Neuroscience.

[10]  Javier DeFelipe,et al.  Sesquicentenary of the birthday of Santiago Ramón y Cajal, the father of modern neuroscience , 2002, Trends in Neurosciences.

[11]  V. Murthy,et al.  Dendritic spines , 1998 .

[12]  F. Freemon.  The Hidden Structure: A Scientific Biography of Camillo Golgi , 2001 .

[13]  N. Fernandez,et al.  Luis Simarro Lacabra [1851–1921]: From Golgi to Cajal Through Simarro, via Ranvier , 2001, Journal of the history of the neurosciences.

[14]  Mnh,et al.  Histologie du Système Nerveux de Lʼhomme et des Vertébrés , 1998 .

[15]  Santiago Ramón y Cajal,et al.  Recuerdos de mi vida: historia de mi labor científica , 1995 .

[16]  S. R. Cajal.  From: ¿Neuronismo o reticularismo? Las pruebas objectivas de la unidad anatómica de las células nerviosas , 1991 .

[17]  R. Sturrock.  Cajal on the Cerebral Cortex. , 1990 .

[18]  M. Frotscher,et al.  The cholinergic innervation of the rat fascia dentata: Identification of target structures on granule cells by combining choline acetyltransferase immunocytochemistry and Golgi impregnation , 1986, The Journal of comparative neurology.

[19]  A. Peters,et al.  A new procedure for examining Golgi impregnated neurons by light and electron microscopy , 1977, Journal of neurocytology.

[20]  A. Peters,et al.  The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines. , 1970, The American journal of anatomy.

[21]  T. Powell,et al.  Morphological variations in the dendritic spines of the neocortex. , 1969, Journal of cell science.

[22]  A. Peters,et al.  The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines. , 1969, Zeitschrift fur Zellforschung und mikroskopische Anatomie.

[23]  E. G. Gray,et al.  Electron Microscopy of Synaptic Contacts on Dendrite Spines of the Cerebral Cortex , 1959, Nature.

[24]  E. Robertis.  Submicroscopic morphology of the synapse. , 1959 .

[25]  S. Palay.  SYNAPSES IN THE CENTRAL NERVOUS SYSTEM , 1956, The Journal of biophysical and biochemical cytology.

[26]  E. De robertis,et al.  SOME FEATURES OF THE SUBMICROSCOPIC MORPHOLOGY OF SYNAPSES IN FROG AND EARTHWORM , 1955, The Journal of biophysical and biochemical cytology.

[27]  G. Palade,et al.  Electron microscope observations of interneuronal and neuromuscular synapses , 1954 .

[28]  Robertson Jd.  Ultrastructure of Two Invertebrate Synapses. , 1953 .

[29]  J. D. Robertson,et al.  Ultrastructure of Two Invertebrate Synapses.∗ , 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[30]  J. Brobeck.  The Integrative Action of the Nervous System , 1948, The Yale Journal of Biology and Medicine.

[31]  W. Smith.  The Integrative Action of the Nervous System , 1907, Nature.

[32]  F. A. David,et al.  A Text-Book on Physiology , 1905, The Indian Medical Gazette.

[33]  A. Bethe.  Allgemeine Anatomie und Physiologie des Nervensystems , 1903 .

[34]  M. Aber,et al.  A NOTE ON THE STAINING OF BRAIN IN A MIXTURE OF METHYLENE BLUE AND PEROXIDE OF HYDROGEN—A VITAL REACTION IN POST-MORTEMTISSUE , 1900 .

[35]  J. Demoor,et al.  La plasticité morphologique des neurones cérébraux , 1897 .

[36]  Semi b. Meyer.  Ueber eine Verbindungsweise der Neuronen Nebst Mittheilungen über die Technik und die Erfolge der Methode der subcutanen Methylenblauinjection , 1896 .

[37]  A. Dogiel.  Die Nervenelemente im Kleinhirne der Vögel und Säugethiere , 1896 .

[38]  Semi b. Meyer.  Die subcutane Methylenblauinjection, ein Mittel zur Darstellung der Elemente des Central-nervensystems Säugethieren , 1895 .

[39]  A. Bethe.  Studien über das Centralnervensystem von Carcinus Maenas nebst Angaben über ein neues Verfahren der Methylenblaufixation , 1895 .

[40]  D. Santiago Ramon Y Cajal,et al.  Nuevo Concepto de la Histologia de los Centros Nerviosos , 1893, The Indian Medical Gazette.

[41]  K. Schaffer.  Beitrag zur Histologie der Ammonshornformation , 1892 .

[42]  W. H. Cox.  Imprägnation des centralen Nervensystems mit Quecksilbersalzen , 1891 .

[43]  G. Retzius.  Ueber den Bau der Oberflächenschicht der Grosshirnrinde beim Menschen und bei den Säugethieren , 1891 .

[44]  S. R. Cajal,et al.  Estructura de los centros nerviosos de las Aves , 1888 .

[45]  P. Ehrlich,et al.  Ueber die Methylenblaureaction der lebenden Nervensubstanz , 1886 .