Tissue injury and healing.

This article provides a primer on the biochemistry of wound healing for clinical oral and maxillofacial surgeons, recognizing that time frames, tissue growth, and cell types are important factors in the healing process that may influence treatment, whereas the specifics of molecular composition and fiber interaction are less critical at the tissue level. Various injury patterns, including different types of lacerations, blunt and penetrating trauma, blast injuries, and ballistic injuries, are described with an eye toward the ultimate clinical goals of functional and cosmetic reconstruction. As injuries of our incredibly brave military soldiers are studied and treated and their outcomes ultimately assessed, they serve as the models to help us understand changing wound patterns and effects in this new age of terroristic warfare.

[1]  L. Kloth,et al.  Wound healing : alternatives in management , 1990 .

[2]  W T Lawrence,et al.  Physiology of the acute wound. , 1998, Clinics in plastic surgery.

[3]  R. Haug,et al.  Firearm injuries to the maxillofacial region: an overview of current thoughts regarding demographics, pathophysiology, and management. , 2003, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[4]  B. McLellan,et al.  Management of blunt trauma , 1990 .

[5]  P. Manson,et al.  The importance of serial debridement and “second-look” procedures in high-energy ballistic and avulsive facial injuries , 1998 .

[6]  Yanpu Liu,et al.  A new model of blast injury from a spherical explosive and its special wound in the maxillofacial region. , 2003, Military medicine.

[7]  P. Singer,et al.  Conventional terrorism and critical care , 2005, Critical care medicine.

[8]  P. Cruse.  Wound Repair, 3rd Edition , 1985 .

[9]  Phillips Jh,et al.  Complex facial trauma: the evolving role of rigid fixation and immediate bone graft reconstruction. , 1989 .

[10]  P. Manson,et al.  High-energy ballistic and avulsive injuries. A management protocol for the next millennium. , 1999, The Surgical clinics of North America.

[11]  Julian A. Smith.  Sabiston. Textbook of Surgery: The Biological Basis of Modern Surgical Practice , 2002 .

[12]  A. Barbul,et al.  General principles of wound healing. , 1997, The Surgical clinics of North America.

[13]  P. Manson,et al.  High‐Energy Ballistic and Avulsive Facial Injuries: Classification, Patterns, and an Algorithm for Primary Reconstruction , 1996, Plastic and reconstructive surgery.

[14]  A. Gillenwater,et al.  Gunshot wounds to the head and neck. , 1992, Archives of otolaryngology--head & neck surgery.

[15]  C. Bartlett,et al.  Clinical update: gunshot wound ballistics. , 2003, Clinical orthopaedics and related research.

[16]  Yao-Jen Chang,et al.  Ballistics for physicians: myths about wound ballistics and gunshot injuries. , 2004, The Journal of urology.

[17]  L D HEATON,et al.  EMERGENCY WAR SURGERY. , 1965, American journal of surgery.

[18]  Joan L. Monaco,et al.  Acute wound healing an overview. , 2003, Clinics in plastic surgery.

[19]  M. Gould,et al.  Terrorism and blast phenomena: lessons learned from the attack on the USS Cole (DDG67). , 2004, Clinical orthopaedics and related research.

[20]  M. Fackler.  Gunshot wound review. , 1996, Annals of emergency medicine.

[21]  D. Steed,et al.  The role of growth factors in wound healing. , 1997, The Surgical clinics of North America.

[22]  F. Wolfort.  Plastic, Maxillofacial and Reconstructive Surgery , 1997 .

[23]  I. K. Cohen,et al.  Wound Healing: Biochemical & Clinical Aspects , 1992 .

[24]  M. Fackler,et al.  Civilian gunshot wounds and ballistics: dispelling the myths. , 1998, Emergency medicine clinics of North America.

[25]  Charles H. Thorne,et al.  Grabb and Smith's Plastic Surgery , 1991 .