Antiarrhythmic Treatment of Atrial Arrhythmias

Summary: Atrial premature beats seldom require an antiarrhythmic treatment; reassurance and suppression of coffee, alcohol, and tobacco generally suffice. Acute atrial fibrillation is best treated by electrical cardioversion if it induces acute cardiovascular decompensation. If it is not poorly tolerated, the arrhythmia may be treated with digitalis at doses sufficient to keep the ventricular response rate at 70–90/min. This therapy may restore sinus rhythm, but conversion to sinus rhythm often requires the combined use of digitalis with a β-blocker or class I antiarrhythmic drug (quinidine, disopyramide, procainamide, propafenone, or flecainide). Digitalis must be avoided in the presence of a preexcitation, and class IA agents, which facilitate atrioventricular (AV) nodal transport, must never be used without digitalis. Chemical cardioversion may also be achieved by i.v. amiodarone. Long-term prevention of recurrences after cardioversion or in the presence of recurrent paroxysmal atrial fibrillation requires digitalis combined with a class I agent, or a β-blocker, preferably sotalol. Amiodarone is also very efficacious. Special mention should be made of atrial fibrillations of vagal or sympathetic origin, which are best treated by amiodarone, or β-blockade (nadolol), respectively. In the presence of chronic established atrial fibrillation, digitalis in combination with a β-blocking agent or a calcium antagonist, such as verapamil or diltiazem, may be useful to slow the ventricular response rate. If successful control cannot be obtained, catheter ablation of the AV node with implantation of a rate-responsive pacemaker must be contemplated. The therapeutic approach in patients with chronic atrial fibrillation, whether or not associated, is similar to atrial flutter. However, flutter may be cardioverted by low-energy shocks (25 J) or, in type I, by rapid atrial pacing. Digitalis may transform atrial flutter into fibrillation, which, in turn, may convert to sinus rhythm after digitalis withdrawal. In exceptional cases, specific atrial surgery or ablation techniques may be proposed. Sinoatrial and atrial reentrant tachycardias may be treated by β-blockade (e.g., sotalol) or class I antiarrhythmic drugs. Automatic atrial tachycardia is frequently caused by digitalis toxicity and can be treated by digitalis withdrawal and K+ replacement. Class I agents may be useful in other etiologies. Atrial tachycardia with block is also associated with digitalis toxicity in >50% of cases; digitalis withdrawal and K+ replacement are mandatory. In patients not receiving digitalis, atrial tachycardia should be managed in the same manner as other tachyarrhythmias of atrial origin.