A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis.

[1]  M. Netea,et al.  Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers* , 2007, Critical care medicine.

[2]  Doron Lancet,et al.  Haplotype structure and selection of the MDM2 oncogene in humans , 2007, Proceedings of the National Academy of Sciences.

[3]  S. Calvano,et al.  GENDER INFLUENCES IN VIVO HUMAN RESPONSES TO ENDOTOXIN , 2006, Shock.

[4]  A. Levine,et al.  MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. , 2006, Cancer research.

[5]  C. Roussos,et al.  Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock? , 2006, Critical care.

[6]  W. Su,et al.  Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. , 2006, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[7]  D. Eccles,et al.  Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers , 2006, BMC Cancer.

[8]  John Savill,et al.  Resolution of inflammation: the beginning programs the end , 2005, Nature Immunology.

[9]  C. Coopersmith,et al.  Prevention of lymphocyte apoptosis--a potential treatment of sepsis? , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  John D. Storey,et al.  A network-based analysis of systemic inflammation in humans , 2005, Nature.

[11]  E. Abraham,et al.  GENETIC POLYMORPHISMS AND SEPSIS , 2005, Shock.

[12]  A. Levine,et al.  A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells* , 2005, Journal of Biological Chemistry.

[13]  E. Hurt,et al.  Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation. , 2005, Cancer research.

[14]  D. Green,et al.  Regulation of arthritis by p53: critical role of adaptive immunity. , 2005, Arthritis and rheumatism.

[15]  A. Levine,et al.  A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans , 2004, Cell.

[16]  F. Finkelman,et al.  Bacterial Lipoprotein Delays Apoptosis in Human Neutrophils through Inhibition of Caspase-3 Activity: Regulatory Roles for CD14 and TLR-2 , 2004, The Journal of Immunology.

[17]  N. Maca-Meyer,et al.  Bench-to-bedside review: Understanding genetic predisposition to sepsis , 2004, Critical care.

[18]  U. Moll,et al.  The MDM2-p53 interaction. , 2003, Molecular cancer research : MCR.

[19]  Guillermina Lozano,et al.  MDM2, an introduction. , 2003, Molecular cancer research : MCR.

[20]  K. Walley,et al.  Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. , 2003, Chest.

[21]  J. Blaydes,et al.  p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. , 2003, Cancer research.

[22]  M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive care medicine.

[23]  N. Risch,et al.  The importance of race and ethnic background in biomedical research and clinical practice. , 2003, The New England journal of medicine.

[24]  José A Fernández,et al.  Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective , 2003, Nature Medicine.

[25]  M. Cutolo,et al.  Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines. , 2002, Rheumatology.

[26]  John David,et al.  Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  I. Chaudry,et al.  Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. , 2001, Cytokine.

[28]  R. Hotchkiss,et al.  p53-Dependent and -Independent Pathways of Apoptotic Cell Death in Sepsis1 , 2000, The Journal of Immunology.

[29]  Hsiao-Huei Wu,et al.  MDM2--master regulator of the p53 tumor suppressor protein. , 2000, Gene.

[30]  G. Hannon,et al.  A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity , 1999, The Journal of experimental medicine.

[31]  K. Kyokane,et al.  Increased mucosal production of granulocyte colony‐stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease , 1999, Journal of gastroenterology and hepatology.

[32]  H. Samuels,et al.  Regulation of the mdm2 Oncogene by Thyroid Hormone Receptor , 1999, Molecular and Cellular Biology.

[33]  J. Vincent,et al.  The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure , 1996, Intensive Care Medicine.

[34]  M. Langer,et al.  The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock , 1995, Intensive Care Medicine.

[35]  S. McClave,et al.  The Acute Physiology and Chronic Health Evaluation II classification system is a valid marker for physiologic stress in the critically ill patient , 1993, Critical care medicine.

[36]  T. Akahoshi,et al.  Prevention of neutrophil apoptosis by monosodium urate crystals , 2005, Rheumatology International.

[37]  S. Hussain,et al.  Nitric oxide and p53 in cancer‐prone chronic inflammation and oxyradical overload disease , 2004, Environmental and molecular mutagenesis.

[38]  D. Green,et al.  Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. , 2002, The American journal of pathology.