Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations
暂无分享,去创建一个
[1] M. Johnston. A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. , 1987, Microbiological reviews.
[2] Jonathan Knowles,et al. A guide to drug discovery: Target selection in drug discovery , 2003, Nature Reviews Drug Discovery.
[3] A. Barabasi,et al. Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.
[4] Andreas Wagner,et al. Estimating coarse gene network structure from large-scale gene perturbation data. , 2002, Genome research.
[5] Michael I. Jordan,et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[6] Jesper Tegnér,et al. Reverse engineering gene networks using singular value decomposition and robust regression , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[7] T. Owa. [Drug target validation and identification of secondary drug target effects using DNA microarrays]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[8] D. Lohr,et al. Transcriptional regulation in the yeast GAL gene family: a complex genetic network , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[9] C. Ball,et al. Saccharomyces Genome Database. , 2002, Methods in enzymology.
[10] J. Hasty,et al. Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[11] Yudong D. He,et al. Functional Discovery via a Compendium of Expression Profiles , 2000, Cell.
[12] R. J. Reece,et al. The insertion of two amino acids into a transcriptional inducer converts it into a galactokinase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[13] J. C. Hinshaw,et al. Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes , 2004, Cell.
[14] Vivek Mittal,et al. Improving the efficiency of RNA interference in mammals , 2004, Nature Reviews Genetics.
[15] Adam A. Margolin,et al. Reverse engineering of regulatory networks in human B cells , 2005, Nature Genetics.
[16] Gustavo Stolovitzky,et al. Reconstructing biological networks using conditional correlation analysis , 2005, Bioinform..
[17] P. Brown,et al. Exploring the metabolic and genetic control of gene expression on a genomic scale. , 1997, Science.
[18] J. Collins,et al. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks , 2005, Nature Biotechnology.
[19] J. Collins,et al. Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling , 2003, Science.
[20] I. Kola,et al. Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.
[21] W. Bandlow,et al. Permanent Nucleosome Exclusion from the Gal4p-inducible YeastGCY1 Promoter* , 2003, The Journal of Biological Chemistry.
[22] R. Albert,et al. The large-scale organization of metabolic networks , 2000, Nature.
[23] Roger E Bumgarner,et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. , 2001, Science.
[24] M. Gerstein,et al. Genomic analysis of regulatory network dynamics reveals large topological changes , 2004, Nature.
[25] Nicola J. Rinaldi,et al. Transcriptional Regulatory Networks in Saccharomyces cerevisiae , 2002, Science.