论文信息 - RAPID RNA CLEAVAGE USING AN ANTISENSE SYSTEM WITH TWO TERPYRIDINE · Cu(II) COMPLEXES

RAPID RNA CLEAVAGE USING AN ANTISENSE SYSTEM WITH TWO TERPYRIDINE · Cu(II) COMPLEXES

An effective approach to promote sequence-specific RNA cleavage by an antisense 2′-O-methyloligonucleotide with a terpyridine · Cu(II) complex attached at the 5′-end was developed. We have synthesized a Cu(II) complex 3′-conjugate, which when used in a tandem fashion, greatly enhanced the RNA cleavage efficiency.

H. Inoue | T. Furukawa | E. Ohtsuka | Takashi Tamura | Akihiro Kamada

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