Hemostatic Markers and Renal Function after Cardiopulmonary Bypass

To evaluate coagulation status after cardiopulmonary bypass and its relation to renal function, thrombin-antithrombin III complex and prothrombin fragment 1+2 were measured as thrombotic markers in 46 patients undergoing coronary artery bypass grafting. Postoperative serum creatinine values exceeded 20 mg·L−1 in 12 patients, indicating compromised renal function; there was a statistically significant increase in the postoperative levels of thrombotic markers in these patients. These data indicate that patients with renal dysfunction after cardiopulmonary bypass have a thrombotic tendency. Anticoagulant treatment is recommended in such patients.

[1]  N. Maurin,et al.  Hemostasis activation markers in acute renal failure. , 1998, Renal failure.

[2]  S. Mezzano,et al.  Hemostatic Disorder of Uremia: The Platelet Defect, Main Determinant of the Prolonged Bleeding Time, Is Correlated with Indices of Activation of Coagulation and Fibrinolysis , 1996, Thrombosis and Haemostasis.

[3]  K. Asada,et al.  Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery. , 1996, Artificial organs.

[4]  F. Valderrábano,et al.  Severe secondary hyperparathyroidism: intravenous calcitriol treatment or parathyroidectomy? , 1996, Clinical nephrology.

[5]  S. Kiraz,et al.  Increased prothrombin fragment 1.2 concentrations in hemodialysis patients. , 1996, Clinical nephrology.

[6]  R. Colman,et al.  Surface-bound heparin fails to reduce thrombin formation during clinical cardiopulmonary bypass. , 1996, The Journal of thoracic and cardiovascular surgery.

[7]  D. Hoppensteadt,et al.  Molecular Markers of Hemostatic Activation: Applications in the Diagnosis of Thrombosis and Vascular and Thrombotic Disorders , 1995 .

[8]  D. Hoppensteadt,et al.  Molecular markers of hemostatic activation. Implications in the diagnosis of thrombosis, vascular, and cardiovascular disorders. , 1995, Clinics in laboratory medicine.

[9]  V. Salandin,et al.  Acute renal failure in the patient undergoing cardiac operation. Prevalence, mortality rate, and main risk factors. , 1994, The Journal of thoracic and cardiovascular surgery.

[10]  J. Paramo,et al.  Thrombin-antithrombin complexes and prothrombin fragment 1+2 in aorto-coronary bypass surgery: relation to graft occlusion. , 1994, Hematologic pathology.

[11]  M. Ferdeghini,et al.  Plasma parameters of the prothrombotic state in chronic uremia. , 1993, Nephron.

[12]  S. Khuri,et al.  Hematologic changes during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss. , 1992, The Journal of thoracic and cardiovascular surgery.

[13]  J. Paramo,et al.  Intra- and postopérative fibronolysis in patients undergoing cardiopulmonary bypass surgery , 1991 .

[14]  A. Koning,et al.  Serious acute renal failure following open heart surgery. , 1985, The Thoracic and cardiovascular surgeon.

[15]  R. Colman,et al.  Platelet function during cardiac operation: comparison of membrane and bubble oxygenators. , 1982, The Journal of thoracic and cardiovascular surgery.