A new sesquiterpene lactone from Sarcandra glabra

A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1–4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC50 > 50 µg mL−1.

[1]  Xu-dong Xu,et al.  Three novel sesquiterpene glycosides of Sarcandra glabra. , 2009, Chemical & pharmaceutical bulletin.

[2]  Dong‐ming Zhang,et al.  Two new sesquiterpene lactones from Sarcandra glabra , 2008, Journal of Asian natural products research.

[3]  Yan Li,et al.  Hepatoprotective sesquiterpene glycosides from Sarcandra glabra. , 2006, Journal of natural products.

[4]  N. Shinohara.  Cytotoxicity, Assays for , 1998 .

[5]  Geoffrey D. Brown,et al.  Cycloeudesmanolides from Sarcandra glabra , 1996 .

[6]  M. Nakatani,et al.  A Revised Structure of Chloranthalactone F and Chloranthalactone A Photodimer. , 1996 .

[7]  H. Okamura,et al.  The Structures of Two Lindenane Sesquiterpene Glucosides from Chloranthus glaber. , 1995 .

[8]  H. Okamura,et al.  The Structures of Two Lindenane Sesquiterpene Glucosides from Chloranthus glaber , 1994 .

[9]  Takashi Matsumoto,et al.  Chloranthalactone F, A sesquiterpenoid from the leaves of Chloranthus glaber , 1993 .

[10]  J. Kawabata,et al.  Shizukanolides D, E and F, Novel Lindenanolides from Chloranthus spp. (Chloranthaceae) , 1989 .

[11]  J. Kawabata,et al.  Studies on the chemical constituents of Chloranthaceae plants. Part VI. Shizukanolides D, E and F, novel lindenanolides from Chloranthus spp. (Chloranthaceae). , 1989 .

[12]  R. Andersson,et al.  Monoaryl and cyclohexenone glycosides from needles of Pinus sylvestris , 1988 .

[13]  R. Xu,et al.  [A new sesquiterpene lactone from Sarcandra glabra]. , 1988, Yao xue xue bao = Acta pharmaceutica Sinica.

[14]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[15]  T. Takemoto,et al.  Studies on the constituents of Chloranthus spp. III. Six sesquiterpenes from Chloranthus japonicus. , 1980 .

[16]  T. Takemoto,et al.  Two New Sesquiterpenoids from Chloranthus glaber Makino , 1978 .