Cardiovascular development: towards biomedical applicability

[1]  Kazuko Koshiba-Takeuchi,et al.  Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. , 2006, Developmental biology.

[2]  L. Perrin,et al.  Control of Cardiac Rhythm by ORK1, a Drosophila Two-Pore Domain Potassium Channel , 2006, Current Biology.

[3]  H. Simon,et al.  LMP4 regulates Tbx5 protein subcellular localization and activity , 2006, The Journal of cell biology.

[4]  B. Bilican,et al.  Cell cycle regulation of the T-box transcription factor tbx2. , 2006, Experimental cell research.

[5]  F. Vitelli,et al.  Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. , 2006, Developmental biology.

[6]  F. Conlon,et al.  TBX5 is required for embryonic cardiac cell cycle progression , 2006, Development.

[7]  D. Srivastava,et al.  Potential of stem-cell-based therapies for heart disease , 2006, Nature.

[8]  A. Moorman,et al.  Formation of the Venous Pole of the Heart From an Nkx2–5–Negative Precursor Population Requires Tbx18 , 2006, Circulation research.

[9]  Roger M. Ilagan,et al.  Fgf8 is required for anterior heart field development , 2006, Development.

[10]  A. Moon,et al.  Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling , 2006, Development.

[11]  B. Morrow,et al.  Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field , 2006, Development.

[12]  Christine L Mummery,et al.  Isl1Cre reveals a common Bmp pathway in heart and limb development , 2006, Development.

[13]  D. Srivastava,et al.  Tbx1 is regulated by forkhead proteins in the secondary heart field † , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[14]  G. Merlo,et al.  Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects. , 2006, European journal of medical genetics.

[15]  Deepak Srivastava,et al.  Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart , 2006, Nature Genetics.

[16]  R. Schwartz,et al.  Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning , 2005, Development.

[17]  E. Olson,et al.  A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  R. Harvey,et al.  T-box transcription factors and their roles in regulatory hierarchies in the developing heart , 2005, Development.

[19]  V. Papaioannou,et al.  T-box genes in vertebrate development. , 2005, Annual review of genetics.

[20]  M. Buckingham,et al.  Building the mammalian heart from two sources of myocardial cells , 2005, Nature Reviews Genetics.

[21]  I. Komuro,et al.  Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases. , 2005, Pharmacology & therapeutics.

[22]  A. Kispert,et al.  Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2 , 2005, Development.

[23]  A. Baldini.  Dissecting contiguous gene defects: TBX1. , 2005, Current opinion in genetics & development.

[24]  M. Rosenfeld,et al.  T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis , 2005, Development.

[25]  B. Bruneau,et al.  Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development , 2005, Development.

[26]  Milena B. Furtado,et al.  Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation , 2005, Development.

[27]  B. Bruneau,et al.  Serum Response Factor, an Enriched Cardiac Mesoderm Obligatory Factor, Is a Downstream Gene Target for Tbx Genes* , 2005, Journal of Biological Chemistry.

[28]  Keith W. Vance,et al.  Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. , 2005, Cancer research.

[29]  Satoru Takahashi,et al.  Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. , 2005, Cancer letters.

[30]  Arnold Munnich,et al.  Mutation in myosin heavy chain 6 causes atrial septal defect , 2005, Nature Genetics.

[31]  R. Kelly.  Molecular inroads into the anterior heart field. , 2005, Trends in cardiovascular medicine.

[32]  F. Conlon,et al.  Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis , 2005, Development.

[33]  K. Yutzey,et al.  T‐box genes and heart development: Putting the “T” in heart , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[34]  Robert H. Anderson,et al.  Reconstruction of the Patterns of Gene Expression in the Developing Mouse Heart Reveals an Architectural Arrangement That Facilitates the Understanding of Atrial Malformations and Arrhythmias , 2004, Circulation research.

[35]  R. Bodmer,et al.  Insulin regulation of heart function in aging fruit flies , 2004, Nature Genetics.

[36]  Jeffrey L. Wrana,et al.  Baf60c is essential for function of BAF chromatin remodelling complexes in heart development , 2004, Nature.

[37]  D. Srivastava,et al.  Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors , 2004, Development.

[38]  A. Moorman,et al.  Architectural plan for the heart: early patterning and delineation of the chambers and the nodes. , 2004, Trends in cardiovascular medicine.

[39]  L. Silver,et al.  Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development , 2004, Development.

[40]  H. Simon,et al.  Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. , 2004, Developmental biology.

[41]  J. Seidman,et al.  The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system , 2004, Development.

[42]  Joe C. Adams,et al.  Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. , 2004, Human molecular genetics.

[43]  B. Bruneau,et al.  Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract , 2004, Development.

[44]  A. Moorman,et al.  The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. , 2004, Cardiovascular research.

[45]  A. Kispert,et al.  The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. , 2004, Genes & development.

[46]  B. Bruneau,et al.  TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed , 2004, Current opinion in cardiology.

[47]  K. Yutzey,et al.  Differential Expression and Function of Tbx5 and Tbx20 in Cardiac Development* , 2004, Journal of Biological Chemistry.

[48]  W. Giles,et al.  Nkx2-5 Pathways and Congenital Heart Disease Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block , 2004, Cell.

[49]  D. Roden,et al.  Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. , 2004, The Journal of clinical investigation.

[50]  A. Moorman,et al.  T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[51]  F. Couch,et al.  The Role of Tbx2 and Tbx3 in Mammary Development and Tumorigenesis , 2004, Journal of Mammary Gland Biology and Neoplasia.

[52]  J. Epstein,et al.  Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. , 2004, Developmental biology.

[53]  Keith W. Vance,et al.  Tbx2 Directly Represses the Expression of the p21WAF1 Cyclin-Dependent Kinase Inhibitor , 2004, Cancer Research.

[54]  Jonathan A. Epstein,et al.  Development Gone Awry: Congenital Heart Disease , 2004, Circulation research.

[55]  M. Kerszberg,et al.  Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis , 2004, The Journal of cell biology.

[56]  Y. Saijoh,et al.  Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis , 2003, Development.

[57]  Yunqing Shi,et al.  Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. , 2003, Developmental cell.

[58]  Mauro W. Costa,et al.  Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. , 2003, Developmental biology.

[59]  A. Moorman,et al.  Cardiac chamber formation: development, genes, and evolution. , 2003, Physiological reviews.

[60]  Jonathan C. Cohen,et al.  GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5 , 2003, Nature.

[61]  T. Ogura,et al.  Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade , 2003, Development.

[62]  Thomas Brand,et al.  Heart development: molecular insights into cardiac specification and early morphogenesis. , 2003, Developmental biology.

[63]  A. Moorman,et al.  Regulatory modules in the developing heart. , 2003, Cardiovascular research.

[64]  Mugen Liu,et al.  Functional Analysis of TBX5 Missense Mutations Associated with Holt-Oram Syndrome* , 2003, The Journal of Biological Chemistry.

[65]  D. Srivastava,et al.  Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. , 2003, Genes & development.

[66]  M. Capecchi,et al.  An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. , 2002, Development.

[67]  K. Yamamura,et al.  Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. , 2002, Development.

[68]  F. Vitelli,et al.  A genetic link between Tbx1 and fibroblast growth factor signaling. , 2002, Development.

[69]  M. van Lohuizen,et al.  The T-box Repressors TBX2 and TBX3Specifically Regulate the Tumor Suppressor Genep14 ARF via a Variant T-site in the Initiator* , 2002, The Journal of Biological Chemistry.

[70]  R. Harvey.  Organogenesis: Patterning the vertebrate heart , 2002, Nature Reviews Genetics.

[71]  A. Meyer,et al.  Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development , 2002, Mechanisms of Development.

[72]  P. Hurlin,et al.  Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation , 2002, Oncogene.

[73]  A. Moorman,et al.  Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. , 2002, Genes & development.

[74]  M. Buckingham,et al.  The anterior heart-forming field: voyage to the arterial pole of the heart. , 2002, Trends in genetics : TIG.

[75]  B. Bruneau.  Transcriptional Regulation of Vertebrate Cardiac Morphogenesis , 2002, Circulation research.

[76]  M. MacDonald,et al.  TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 ARF and Inhibits Senescence* , 2002, The Journal of Biological Chemistry.

[77]  C. Basson,et al.  Getting the T-box dose right , 2001, Nature Medicine.

[78]  P. Hurlin,et al.  A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. , 2001, Human molecular genetics.

[79]  J. Schmitt,et al.  A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease , 2001, Cell.

[80]  D. Srivastava,et al.  Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. , 2001, Developmental biology.

[81]  Ryozo Nagai,et al.  Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation , 2001, Nature Genetics.

[82]  P. Chambon,et al.  Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. , 2001, Development.

[83]  V. Papaioannou,et al.  DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1 , 2001, Nature Genetics.

[84]  Birgit Funke,et al.  TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome , 2001, Cell.

[85]  T. Mikawa,et al.  TBX5 transcription factor regulates cell proliferation during cardiogenesis. , 2001, Developmental biology.

[86]  A. Kispert,et al.  Cloning and expression analysis of the mouse T-box gene Tbx18 , 2001, Mechanisms of Development.

[87]  A. Kispert,et al.  Cloning and expression analysis of the mouse T-box gene Tbx20 , 2001, Mechanisms of Development.

[88]  N. Rosenthal,et al.  From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation. , 2000, Current opinion in cell biology.

[89]  G. Eichele,et al.  Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. , 2000, Developmental biology.

[90]  R. Gronostajski,et al.  Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. , 2000, Gene.

[91]  Marc J. van de Vijver,et al.  Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers , 2000, Nature Genetics.

[92]  P. Scambler.  The 22q11 deletion syndromes. , 2000, Human molecular genetics.

[93]  A. Moorman,et al.  Chamber formation and morphogenesis in the developing mammalian heart. , 2000, Developmental biology.

[94]  K. Yutzey,et al.  Ventricular expression of tbx5 inhibits normal heart chamber development. , 2000, Developmental biology.

[95]  Y. Rao,et al.  Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[96]  J. Seidman,et al.  Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. , 1999, Developmental biology.

[97]  Concepción Rodríguez-Esteban,et al.  The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity , 1999, Nature.

[98]  J. Seidman,et al.  Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[99]  S. Izumo,et al.  The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. , 1999, Development.

[100]  C. R. Goding,et al.  Brachyury-Related Transcription Factor Tbx2 and Repression of the Melanocyte-Specific TRP-1 Promoter , 1998, Molecular and Cellular Biology.

[101]  J. Seidman,et al.  Congenital heart disease caused by mutations in the transcription factor NKX2-5. , 1998, Science.

[102]  C. Müller,et al.  Crystallographic structure of the T domain–DNA complex of the Brachyury transcription factor , 1997, Nature.

[103]  J. Seidman,et al.  Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome , 1997, Nature Genetics.

[104]  L. Silver,et al.  Expression of the T‐box family genes, Tbx1–Tbx5, during early mouse development , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[105]  L. Silver,et al.  Identification, characterization, and localization to Chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family , 1995, Mammalian Genome.

[106]  B. Beatty,et al.  Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. , 1995, Genomics.

[107]  Ruili Li,et al.  Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. , 1995, Genes & development.

[108]  J. Rossant,et al.  Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. , 1993, Development.

[109]  R. Bodmer.  The gene tinman is required for specification of the heart and visceral muscles in Drosophila. , 1993, Development.

[110]  V. Stewart,et al.  Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. , 1992, Genes & development.

[111]  A. Poustka,et al.  Cloning of the T gene required in mesoderm formation in the mouse , 1990, Nature.

[112]  T. Ogura,et al.  Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling. , 2004, Developmental cell.

[113]  A. Moorman,et al.  TBX5 overexpression stimulates differentiation of chamber myocardium in P19Cl6 embryonic carcinoma cells , 2004, Journal of Muscle Research & Cell Motility.

[114]  R. Kucherlapati,et al.  Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome , 1997, Nature Genetics.

[115]  David I. Wilson,et al.  Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family , 1997, Nature Genetics.