The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

The various mechanisms which have been advanced to explain drug absorption are critically reviewed and the limitations of current theories are discussed. Various techniques for investigating drug absorption and transit through the gut are presented, and the results obtained with metoprolol are briefly considered to illustrate the potential of some of these methods.

[1]  B. Brodie,et al.  On the mechanism of intestinal absorption of drugs. , 1959, The Journal of pharmacology and experimental therapeutics.

[2]  J. Dietschy,et al.  Unstirred Water Layers in Intestine: Rate Determinant of Fatty Acid Absorption from Micellar Solutions , 1971, Science.

[3]  P. Tothill,et al.  An evaluation of 113mindium DTPA chelate in the measurement of gastric emptying by scintiscanning , 1971, Gut.

[4]  A. Gérardin,et al.  An incremental method for the study of the absorption of drugs whose kinetics are described by a two-compartment model: Estimation of the microscopic rate constants , 1983, Journal of Pharmacokinetics and Biopharmaceutics.

[5]  L F Prescott,et al.  Kinetics of acetaminophen absorption and gastric emptying in man , 1978, Clinical pharmacology and therapeutics.

[6]  J. Bernier,et al.  Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum. , 1985, British journal of clinical pharmacology.

[7]  C. Hogben.  Alimentary Tract , 2004, Abdominal Imaging.

[8]  B. Borgström,et al.  Studies of intestinal digestion and absorption in the human. , 1957, The Journal of clinical investigation.

[9]  W. Nimmo.  Drugs, Diseases and Altered Gastric Emptying , 1976, Clinical pharmacokinetics.

[10]  S. Riegelman,et al.  New method for calculating the intrinsic absorption rate of drugs. , 1968, Journal of pharmaceutical sciences.

[11]  R. R. Levine,et al.  The influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine. , 1961, The Journal of pharmacology and experimental therapeutics.

[12]  C. Johansson.  Studies in gastrointestinal interactions. IV. Gastric emptying of a composite meal in man. The influence of glucose. , 1973, Scandinavian journal of gastroenterology.

[13]  B. Brodie,et al.  The gastric secretion of drugs: a pH partition hypothesis. , 1957, The Journal of pharmacology and experimental therapeutics.

[14]  D. Wade,et al.  A pharmacological method of measuring mouth caecal transit time in man. , 1979, British journal of clinical pharmacology.

[15]  N. Vidon,et al.  Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon. , 1985, British journal of clinical pharmacology.

[16]  J Hellemans,et al.  The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. , 1977, The Journal of clinical investigation.

[17]  J. Wagner,et al.  Per cent absorbed time plots derived from blood level and/or urinary excretion data. , 1963, Journal of pharmaceutical sciences.

[18]  A. K. Solomon,et al.  ION AND WATER FLUXES IN THE ILEUM OF RATS , 1957, The Journal of general physiology.

[19]  M. Rongier,et al.  Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum. , 1985, British journal of clinical pharmacology.

[20]  A. Melander,et al.  Influence of Food on the Bioavailability of Drugs , 1978, Clinical pharmacokinetics.

[21]  C. Johansson.  Studies of gastrointestinal interactions. VII. Characteristics of the absorption pattern of sugar, fat and protein from composite meals in man. A quantitative study. , 1975, Scandinavian journal of gastroenterology.

[22]  J. Malagelada.  Quantificantion of gastric solid-liquid discrimination during digestion of ordinary meals. , 1977, Gastroenterology.