Haunted by the past: old emotions remain salient in insomnia disorder

Sleep supports changes in the neuronal representation of emotional experiences to make those experiences less distressing when subsequently recalled. Wassing et al. show that individuals with insomnia disorder activate the anterior cingulate cortex during both new and relived emotional experiences. The findings suggest insufficient adaptation to emotional distress in people who are vulnerable to developing insomnia disorder.

[1]  F. Bloom,et al.  Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[2]  F. Bloom,et al.  Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  C. Olson,et al.  Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. , 1992, Cerebral cortex.

[4]  C. Bell.  DSM-IV: Diagnostic and Statistical Manual of Mental Disorders , 1994 .

[5]  Daniel J Buysse,et al.  The use of polysomnography in the evaluation of insomnia. , 1995, Sleep.

[6]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[7]  A. Chesson,et al.  Practice parameters for the use of polysomnography in the evaluation of insomnia. Standards of Practice Committee of the American Sleep Disorders Association. , 1995, Sleep.

[8]  J. Gaillard,et al.  Spectral characteristics of sleep EEG in chronic insomnia , 1998, The European journal of neuroscience.

[9]  M. Posner,et al.  Cognitive and emotional influences in anterior cingulate cortex , 2000, Trends in Cognitive Sciences.

[10]  D. Giles,et al.  Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. , 2001, Sleep.

[11]  Q. Regestein,et al.  Self-reported hyperarousal traits among insomnia patients. , 2001, Journal of psychosomatic research.

[12]  Stephen M. Smith,et al.  Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data , 2001, NeuroImage.

[13]  J. Hobson,et al.  The cognitive neuroscience of sleep: neuronal systems, consciousness and learning , 2002, Nature Reviews Neuroscience.

[14]  J. Born,et al.  Changes in Emotional Responses to Aversive Pictures Across Periods Rich in Slow-Wave Sleep Versus Rapid Eye Movement Sleep , 2002, Psychosomatic medicine.

[15]  B. Mensour,et al.  Neural circuitry underlying voluntary suppression of sadness , 2003, Biological Psychiatry.

[16]  Stephen M. Smith,et al.  General multilevel linear modeling for group analysis in FMRI , 2003, NeuroImage.

[17]  Thomas E. Nichols,et al.  Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI study , 2003, Biological Psychiatry.

[18]  C. Morin,et al.  Role of Stress, Arousal, and Coping Skills in Primary Insomnia , 2003, Psychosomatic medicine.

[19]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[20]  Jonathan D. Cohen,et al.  Conflict monitoring and anterior cingulate cortex: an update , 2004, Trends in Cognitive Sciences.

[21]  Mark W. Woolrich,et al.  Multilevel linear modelling for FMRI group analysis using Bayesian inference , 2004, NeuroImage.

[22]  B. Vogt.  Pain and emotion interactions in subregions of the cingulate gyrus , 2005, Nature Reviews Neuroscience.

[23]  K. Phan,et al.  Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study , 2005, Biological Psychiatry.

[24]  R. Cabeza,et al.  Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  L. Mccloskey,et al.  The Relation of Child Maltreatment to Shame and Guilt Among Adolescents: Psychological Routes to Depression and Delinquency , 2005, Child maltreatment.

[26]  Rami K. Niazy,et al.  Removal of FMRI environment artifacts from EEG data using optimal basis sets , 2005, NeuroImage.

[27]  L. Taska,et al.  The Persistence of Shame Following Sexual Abuse: A Longitudinal Look at Risk and Recovery , 2005, Child maltreatment.

[28]  B. McNaughton,et al.  Declarative memory consolidation in humans: a prospective functional magnetic resonance imaging study. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Heather L. Urry,et al.  Amygdala and Ventromedial Prefrontal Cortex Are Inversely Coupled during Regulation of Negative Affect and Predict the Diurnal Pattern of Cortisol Secretion among Older Adults , 2006, The Journal of Neuroscience.

[30]  J. Born,et al.  Brief Sleep After Learning Keeps Emotional Memories Alive for Years , 2006, Biological Psychiatry.

[31]  F. Sarrais,et al.  [The insomnia]. , 2007, Anales del sistema sanitario de Navarra.

[32]  A. Etkin,et al.  Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. , 2007, The American journal of psychiatry.

[33]  Manuel Schabus,et al.  Sleep transforms the cerebral trace of declarative memories , 2007, Proceedings of the National Academy of Sciences.

[34]  M. Walker,et al.  The human emotional brain without sleep — a prefrontal amygdala disconnect , 2007, Current Biology.

[35]  Manuel Schabus,et al.  Sleep-Related Hippocampo-Cortical Interplay during Emotional Memory Recollection , 2007, PLoS biology.

[36]  A. Chesson,et al.  The American Academy of Sleep Medicine (AASM) Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications , 2007 .

[37]  D. Rubin,et al.  The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving. , 2008, Cerebral cortex.

[38]  K. R. Ridderinkhof,et al.  Striatum and pre-SMA facilitate decision-making under time pressure , 2008, Proceedings of the National Academy of Sciences.

[39]  B. Feige,et al.  Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients , 2008, Journal of sleep research.

[40]  M. Desseilles,et al.  Sleep Promotes the Neural Reorganization of Remote Emotional Memory , 2009, The Journal of Neuroscience.

[41]  T. Nielsen,et al.  Overnight emotional adaptation to negative stimuli is altered by REM sleep deprivation and is correlated with intervening dream emotions , 2009, Journal of sleep research.

[42]  Sang Won Seo,et al.  Defining functional SMA and pre-SMA subregions in human MFC using resting state fMRI: Functional connectivity-based parcellation method , 2010, NeuroImage.

[43]  M. Bonnet,et al.  Hyperarousal and insomnia: state of the science. , 2010, Sleep medicine reviews.

[44]  B. Feige,et al.  The hyperarousal model of insomnia: a review of the concept and its evidence. , 2010, Sleep medicine reviews.

[45]  Daniel J Buysse,et al.  Night-to-night sleep variability in older adults with and without chronic insomnia. , 2010, Sleep medicine.

[46]  I. Rampil,et al.  Where is the impact? , 2010, Anesthesiology.

[47]  Christine M. Walsh,et al.  Cognitive neuroscience of sleep. , 2010, Progress in brain research.

[48]  Elizabeth A. Kensinger,et al.  Sleep Leads to Changes in the Emotional Memory Trace: Evidence from fMRI , 2011, Journal of Cognitive Neuroscience.

[49]  H. Critchley,et al.  The impact of overnight consolidation upon memory for emotional and neutral encoding contexts , 2011, Neuropsychologia.

[50]  G. Hein,et al.  Skin Conductance Response to the Pain of Others Predicts Later Costly Helping , 2011, PloS one.

[51]  M. Walker,et al.  REM Sleep Depotentiates Amygdala Activity to Previous Emotional Experiences , 2011, Current Biology.

[52]  U. Wagner,et al.  Guilt-specific processing in the prefrontal cortex. , 2011, Cerebral cortex.

[53]  I. L. Nieuwenhuis,et al.  The role of the ventromedial prefrontal cortex in memory consolidation , 2011, Behavioural Brain Research.

[54]  T. Egner,et al.  Emotional processing in anterior cingulate and medial prefrontal cortex , 2011, Trends in Cognitive Sciences.

[55]  R. Stickgold,et al.  Napping promotes inter-session habituation to emotional stimuli , 2011, Neurobiology of Learning and Memory.

[56]  M. Walker,et al.  A role for REM sleep in recalibrating the sensitivity of the human brain to specific emotions. , 2011, Cerebral cortex.

[57]  C. Morin,et al.  The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. , 2011, Sleep.

[58]  J. Os,et al.  The size and burden of mental disorders and other disorders of the brain in Europe 2010 , 2011, European Neuropsychopharmacology.

[59]  J. Armony,et al.  Enhanced emotional reactivity after selective REM sleep deprivation in humans: an fMRI study , 2012, Front. Behav. Neurosci..

[60]  B. Feige,et al.  REM Sleep Instability – A New Pathway for Insomnia? , 2012, Pharmacopsychiatry.

[61]  D. Plante,et al.  Reduced γ-Aminobutyric Acid in Occipital and Anterior Cingulate Cortices in Primary Insomnia: a Link to Major Depressive Disorder? , 2012, Neuropsychopharmacology.

[62]  R. Spencer,et al.  Processing of Emotional Reactivity and Emotional Memory over Sleep , 2012, The Journal of Neuroscience.

[63]  I. Wilhelm,et al.  System consolidation of memory during sleep , 2011, Psychological Research.

[64]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[65]  Julia S. Rihm,et al.  The role of sleep and sleep deprivation in consolidating fear memories , 2013, NeuroImage.

[66]  I. Wilhelm,et al.  The role of REM sleep in the processing of emotional memories: Evidence from behavior and event-related potentials , 2013, Neurobiology of Learning and Memory.

[67]  B. Feige,et al.  The microstructure of sleep in primary insomnia: an overview and extension. , 2013, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[68]  B. Miller,et al.  Role of right pregenual anterior cingulate cortex in self-conscious emotional reactivity. , 2013, Social cognitive and affective neuroscience.

[69]  Marijn C. W. Kroes,et al.  An fMRI investigation of posttraumatic flashbacks , 2013, Brain and Cognition.

[70]  I. Liberzon,et al.  Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD , 2014, Experimental Brain Research.

[71]  F. Schalkwijk.  The Conscience and Self-Conscious Emotions in Adolescence: An integrative approach , 2014 .

[72]  Stephen M. Mattingly,et al.  Psychophysiological arousal at encoding leads to reduced reactivity but enhanced emotional memory following sleep , 2014, Neurobiology of Learning and Memory.

[73]  Alberto Llera,et al.  ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data , 2015, NeuroImage.

[74]  Paul Antoine Salin,et al.  The supramammillary nucleus and the claustrum activate the cortex during REM sleep , 2015, Science Advances.

[75]  M. Milad,et al.  Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory , 2015, Biology of Mood & Anxiety Disorders.

[76]  Sabina Khantsis,et al.  Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress , 2016, Brain Research.

[77]  B. Feige,et al.  Slow dissolving of emotional distress contributes to hyperarousal , 2016, Proceedings of the National Academy of Sciences.

[78]  O. Koenig,et al.  Relearn Faster and Retain Longer , 2016, Psychological science.

[79]  H. Stefánsson,et al.  Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits , 2017, Nature Genetics.

[80]  B. Bjorvatn,et al.  High prevalence of insomnia and hypnotic use in patients visiting their general practitioner , 2017, Family practice.

[81]  E. V. van Someren,et al.  Insomnia heterogeneity: Characteristics to consider for data-driven multivariate subtyping. , 2017, Sleep medicine reviews.

[82]  P. Luppi,et al.  Selective activation of a few limbic structures during paradoxical (REM) sleep by the claustrum and the supramammillary nucleus: evidence and function , 2017, Current Opinion in Neurobiology.

[83]  A. Auton,et al.  Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways , 2019, Nature Genetics.

[84]  M. Kindt.  The surprising subtleties of changing fear memory: a challenge for translational science , 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

[85]  S. Eickhoff,et al.  A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis. , 2018, Sleep medicine reviews.

[86]  D. Tempesta,et al.  Sleep and emotional processing. , 2017, Sleep medicine reviews.

[87]  G. Vandewalle,et al.  The genetic liability for insomnia is associated with lower amount of slow wave sleep in young and healthy individuals , 2018 .

[88]  Elena M. Vazey,et al.  Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory , 2018, Current Biology.

[89]  C. Schwechheimer,et al.  DiSUMO-LIKE Interacts with RNA-Binding Proteins and Affects Cell-Cycle Progression during Maize Embryogenesis , 2018, Current Biology.

[90]  M. Milad,et al.  Delayed fear extinction in individuals with insomnia disorder , 2018, Sleep.

[91]  E. V. van Someren,et al.  Overnight worsening of emotional distress indicates maladaptive sleep in insomnia , 2018, Sleep.