Application of laser speckle contrast image in the evaluation of arthritis animal model

Arthritis is a chronic inflammatory disease that induces potentially damaging and commonly disabling. Various imaging modalities have been used for the evaluation of arthritis. This study aimed to investigate the feasibility of laser speckle contrast image (LSCI) in the evaluation of the severity and early stage of arthritis in animal model. Arthritis was induced on mouse foot and evaluated by a trained expert and the LSCI. The arthritis severity was quantitatively evaluated by speckle index (SI) computed from LSCI. In visual inspection by an expert, it was difficult to evaluate the arthritis because there was no noticeable different between control mouse group (CMG) and arthritis mouse group (AMG) in erythema. However, arthritis was easily evaluated by significant SI different between the CMG and AMG. In addition, the LSCI also successfully evaluated the early stage of arthritis, presenting different SI distribution depending on lesion.

[1]  P. Warter.  Diagnosis and management of rheumatoid arthritis. , 1956, Medical times.

[2]  N. Borisch,et al.  [Imaging in rheumatoid arthritis of the elbow]. , 2003, Der Orthopade.

[3]  M. Ostergaard,et al.  Established rheumatoid arthritis - new imaging modalities. , 2007, Best practice & research. Clinical rheumatology.

[4]  D. Chamberland,et al.  Optical imaging: new tools for arthritis. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[5]  Olaf Minet,et al.  Diagnosis of rheumatoid arthritis using light: correction of motion artefacts and color visualization of multispectral images. , 2010, Journal of biophotonics.

[6]  Ngee Han Lim,et al.  In vivo optical imaging in arthritis--an enlightening future? , 2010, Rheumatology.

[7]  Ernst Rummeny,et al.  Optical imaging of rheumatoid arthritis. , 2011, International journal of clinical rheumatology.

[8]  J. Dunn,et al.  A transmissive laser speckle imaging technique for measuring deep tissue blood flow: An example application in finger joints , 2011, Lasers in surgery and medicine.

[9]  Anna Devor,et al.  Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. , 2005, Applied optics.

[10]  Paul Emery,et al.  Imaging in early arthritis. , 2004, Best practice & research. Clinical rheumatology.

[11]  Bernard Choi,et al.  Linear response range characterization and in vivo application of laser speckle imaging of blood flow dynamics. , 2006, Journal of biomedical optics.