Cerebrospinal Fluid Lactate Dehydrogenase in Neonatal Intracranial Hemorrhage

Cerebrospinal fluid (CSF) lactate dehydrogenase (LDH) was measured in 54 neonates with intracranial hemorrhage and compared with 82 control, 27 traumatic lumbar puncture, seven meningitis, and 30 asphyxiated newborns. Hospital data, neonatal outcomes, and long-term neurodevelopmental follow-up results were reviewed. CSF LDH was not significantly affected by traumatic lumbar puncture but was elevated in proportion to the severity of CNS hemorrhage as scored by computerized to mography. LDH was also significantly associated with subsequent seizures and hydrocephalus and abnormal long-term developmental outcome.

[1]  S. Engelke,et al.  The coastal plains region neonatal follow-up program: preliminary results. , 1982, North Carolina medical journal.

[2]  B. Dalens,et al.  Enzyme studies and neonatal brain damage , 1981, Acta paediatrica Scandinavica.

[3]  J. Knight,et al.  Early (chemical) diagnosis of bacterial meningitis--cerebrospinal fluid glucose, lactate, and lactate dehydrogenase compared. , 1981, Clinical chemistry.

[4]  Hutchson Aa,et al.  A classification of neonatal intracranial hemorrhage. , 1981 .

[5]  J. Viallard,et al.  CSF Levels of Lactate and Hydroxybutyrate Dehydrogenase as Indicators of Neurological Sequelae after Neonatal Brain Damage , 1981, Developmental Medicine & Child Neurology.

[6]  P. Ahmann,et al.  Reliability of ultrasound in diagnosis of intracerebral hemorrhage and posthemorrhagic hydrocephalus: comparison with computed tomography. , 1980, Pediatrics.

[7]  P. Rhodes,et al.  Cerebrospinal Fluid Lactate Dehydrogenase in Infants with Perinatal Asphyxia , 1980 .

[8]  R. Schreiner,et al.  Incidence and Effect of Traumatic Lumbar Puncture in the Neonate , 1979, Developmental medicine and child neurology.

[9]  A. Pollard,et al.  Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders. , 1975, Journal of clinical pathology.

[10]  R. Hawkins,et al.  The Clinical Value of Cerebrospinal Fluid Lactic Dehydrogenase Determinations in Children with Bacterial Meningitis and other Neurological Disorders , 1968, Developmental medicine and child neurology.

[11]  W. Neches,et al.  Cerebrospinal fluid LDH in 287 children, including 53 cases of meningitis of bacterial and non-bacterial etiology. , 1968, Pediatrics.

[12]  L. Slobody,et al.  CEREBROSPINAL FLUID GLUTAMIC OXALACETIC TRANSAMINASE AND LACTIC DEHYDROGENASE ACTIVITIES IN CHILDREN WITH NEUROLOGIC DISORDERS. , 1964, The Journal of pediatrics.

[13]  H. J. Helm,et al.  ISOENZYMES IN DIFFERENT PARTS OF THE BRAIN , 1962 .

[14]  M. L. Stone,et al.  Activity of glutamic-oxalacetic transminase and lactic dehydrogenase in cerebrospinal fluid and plasma of normal and abnormal newborn infants. , 1959, Pediatrics.

[15]  B. Vallee,et al.  Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. , 1956, The New England journal of medicine.

[16]  T. L. Coombs,et al.  Metalloenzymes and myocardial infarction. I. The relation between serum copper and ceruloplasmin and its catalytic activity. , 1956, The New England journal of medicine.