论文信息 - Analysis of Ambroxol Hydrochloride in Flavamed® Tablets by Means of Spectroscopic Absorption Methods

Analysis of Ambroxol Hydrochloride in Flavamed® Tablets by Means of Spectroscopic Absorption Methods

Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. It is a metabolic product of bromhexin and it is used as broncho secretolytic and an expectorant drug. Analysis of Flavamed® tablets, in which ambroxol hydrochloride (AMB) is an active component, was performed. UV/VIS spectrophotometry and atomic absorption spectroscopy (AAS) were used. Direct and indirect UV/VIS spectrophotometric methods were used for quantitative analysis of AMB and the following recovery value results were obtained: 100,16% and 95,23%, successively. Content of heavy metals in Flavamed® tablets was determined by atomic absorption spetroscopy.

[1] R. Rajan. Simple Spectrophotometric Methods For Determination Of Ambroxol Hydrochloride From Pharmaceutical Formulation , 2012 .

[2] R. Patel. Stability-Indicating HPTLC Determination of Ambroxol Hydrochloride in Bulk Drug and Pharmaceutical Dosage Form , 2012 .

[3] N. Bhatia,et al. Spectrophotometric estimation of ambroxol hydrochloride and cetirizine hydrochloride in tablets , 2008 .

[4] K. Pasha,et al. Spectrophotometric determination of ambroxol hydrochloride , 2005 .

[5] N. Abdel-Ghani,et al. Determination of ambroxol hydrochloride in pure solutions and some of its pharmaceutical preparations under batch and FIA conditions. , 2003, Farmaco.