Molybdenum Disulfide/Nickel-Metal Organic Framework Hybrid Nanosheets Based Disposable Electrochemical Sensor for Determination of 4-Aminophenol in Presence of Acetaminophen

The toxicity of commonly used drugs, such as acetaminophen (ACAP) and its degradation-derived metabolite of 4-aminophenol (4-AP), underscores the need to achieve an effective approach in their simultaneous electrochemical determination. Hence, the present study attempts to introduce an ultra-sensitive disposable electrochemical 4-AP and ACAP sensor based on surface modification of a screen-printed graphite electrode (SPGE) with a combination of MoS2 nanosheets and a nickel-based metal organic framework (MoS2/Ni-MOF/SPGE sensor). A simple hydrothermal protocol was implemented to fabricate MoS2/Ni-MOF hybrid nanosheets, which was subsequently tested for properties using valid techniques including X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX), Fourier transformed infrared spectroscopy (FTIR), and N2 adsorption-desorption isotherm. The 4-AP detection behavior on MoS2/Ni-MOF/SPGE sensor was followed by cyclic voltammetry (CV), chronoamperometry and differential pulse voltammetry (DPV). Our experimental findings on the generated sensor confirmed a broad linear dynamic range (LDR) for 4-AP from 0.1 to 600 μM with a high sensitivity of 0.0666 μA/μM and a low limit of detection (LOD) of 0.04 μM. In addition, an analysis of real specimens such as tap water sample as well as a commercial sample (acetaminophen tablets) illuminated the successful applicability of as-developed sensor in determining ACAP and 4-AP, with an impressive recovery rate.

[1]  F. Fazeli,et al.  An overview of recent advances in the detection of ascorbic acid by electrochemical techniques , 2022, Journal of Electrochemical Science and Engineering.

[2]  Yasser Fakri Mustafa,et al.  Electrochemical detection of sulfite in food samples , 2022, Journal of Electrochemical Science and Engineering.

[3]  Y. Vasseghian,et al.  Determination of D&C Red 33 and Patent Blue V Azo dyes using an impressive electrochemical sensor based on carbon paste electrode modified with ZIF-8/g-C3N4/Co and ionic liquid in mouthwash and toothpaste as real samples. , 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  Mohammad Reza Aflatoonian,et al.  A sensitive Cu(salophen) modified screen-printed electrode for simultaneous determination of dopamine and uric acid , 2022, Journal of Electrochemical Science and Engineering.

[5]  Mohammad Reza Aflatoonian,et al.  Glutathione detection at carbon paste electrode modified with ethyl 2-(4-Ferrocenyl-[1,2,3]Triazol-1-yl)acetate, ZnFe2O4 nanoparticles and ionic liquid , 2022, Journal of Electrochemical Science and Engineering.

[6]  Yue Zhang,et al.  A novel enhanced electrochemical sensor based on the peroxidase-like activity of Fe3O4@Au/MOF for the detection of p-aminophenol , 2022, Journal of Applied Electrochemistry.

[7]  Lingli Zhang,et al.  A simple sensing platform based on 1T@2H-MoS2/cMWCNTs composite modified electrode for ultrasensitive detection of the illegal Sudan I dye in food samples , 2022, Analytical Methods.

[8]  Hao Guo,et al.  Highly sensitive determination of acetaminophen and 4-aminophenol based on COF/3D NCNF-T/Au NPs composite electrochemical sensing platform , 2021, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

[9]  H. Peyman,et al.  PVC Membrane Electrode Modified by Lawson as Synthetic Derivative Ionophore for Determination of Cadmium in Alloy and Wastewater , 2021 .

[10]  Razieh Sanavi Khoshnood,et al.  Fabrication a composite carbon paste electrodes (CPEs) modified with multi-wall carbon nano-tubes (MWCNTs/N, N-Bis (salicyliden)-1,3-propandiamine) for determination of lanthanum (III) , 2021 .

[11]  B. Ye,et al.  Electrochemical sensor based on N-doped carbon dots decorated with manganese oxide nanospheres for simultaneous detection of p-aminophenol and paracetamol. , 2021, The Analyst.

[12]  Tuğba Tabanlıgil Calam.  A modified pencil graphite electrode with 2-thiobarbituric acid for the efficient and cheap voltammetric sensing of 4-aminophenol in water samples and child syrup sample , 2021 .

[13]  Kai Feng,et al.  Self-assembly of MoS2 nanosheet on functionalized pomelo peel derived carbon and its electrochemical sensor behavior toward taxifolin , 2021, Inorganic Chemistry Communications.

[14]  Hao Guo,et al.  MoS2/Ni(OH)2 composites derived from in situ grown Ni-MOF coating MoS2 as electrode materials for supercapacitor and electrochemical sensor , 2021 .

[15]  M. Mirzaei,et al.  In silico investigation of nanocarbon biosensors for diagnosis of COVID-19 , 2021 .

[16]  M. Ebrahimi,et al.  The Simultaneous Spectrophotometric Determination of Acetaminophen, Celecoxib, Diazepam, and Famotidine in Environmental Samples by Partial Least Squares , 2021 .

[17]  Hui Dong,et al.  Electrochemical immunosensor based on Au/Co-BDC/MoS2 and DPCN/MoS2 for the detection of cardiac troponin I. , 2020, Biosensors & bioelectronics.

[18]  M. M. Rahman.  Selective and sensitive 4-Aminophenol chemical sensor development based on low-dimensional Ge-doped ZnO nanocomposites by electrochemical method , 2020 .

[19]  Yanming Liu,et al.  Highly Sensitive and Selective Electrochemical Determination of 4-Aminophenol Based on Flower-Like Ag-Au Nanocomposites Modified Glassy Carbon Electrode , 2020 .

[20]  S. Balakumar,et al.  Facile synthesis of paper based graphene electrodes for point of care devices: A double stranded DNA (dsDNA) biosensor. , 2020, Journal of colloid and interface science.

[21]  Shambhulinga Aralekallu,et al.  Simultaneous detection of paracetamol and 4-aminophenol at nanomolar levels using biocompatible cysteine-substituted phthalocyanine , 2020 .

[22]  Xinyu Jiang,et al.  A sensitive sensor based on MOFs derived nanoporous carbons for electrochemical detection of 4-aminophenol. , 2020, Ecotoxicology and environmental safety.

[23]  G. Nageswaran,et al.  Review—2D Layered Metal Organic Framework Nanosheets as an Emerging Platform for Electrochemical Sensing , 2020, Journal of The Electrochemical Society.

[24]  S. Sriram,et al.  Photocatalytic activity of MoS2 nanoparticles: an experimental and DFT analysis , 2019, Applied Physics A.

[25]  Yingchun Li,et al.  Simultaneous determination of paracetamol and p-aminophenol using glassy carbon electrode modified with nitrogen- and sulfur- co-doped carbon dots , 2019, Microchimica Acta.

[26]  Siyu Zhang,et al.  Simultaneous detection of acetaminophen and 4-aminophenol with an electrochemical sensor based on silver–palladium bimetal nanoparticles and reduced graphene oxide , 2019, RSC advances.

[27]  Tuğba Tabanlıgil Calam,et al.  Rapid and Selective Determination of Vanillin in the Presence of Caffeine, its Electrochemical Behavior on an Au Electrode Electropolymerized with 3‐Amino‐1,2,4‐triazole‐5‐thiol , 2019, Electroanalysis.

[28]  T. M. Reddy,et al.  Multi walled carbon nanotubes supported CuO-Au hybrid nanocomposite for the effective application towards the electrochemical determination of Acetaminophen and 4-Aminophenol , 2019, Synthetic Metals.

[29]  A. Kawde,et al.  A hybrid nanocomposite of CeO2–ZnO–chitosan as an enhanced sensing platform for highly sensitive voltammetric determination of paracetamol and its degradation product p-aminophenol , 2019, RSC advances.

[30]  William R. Smith,et al.  Ultrathin MoS2 Nanosheets Decorated Hollow CoP Heterostructures for Enhanced Hydrogen Evolution Reaction , 2019, ACS Sustainable Chemistry & Engineering.

[31]  Min Zhou,et al.  3D multiporous Co,N co-doped MoO2/MoC nanorods hybrids as improved electrode materials for highly sensitive simultaneous determination of acetaminophen and 4-aminophenol , 2019, Electrochimica Acta.

[32]  S. Qiao,et al.  Engineering 2D Metal-Organic Framework/MoS2 Interface for Enhanced Alkaline Hydrogen Evolution. , 2019, Small.

[33]  S. Agarwal,et al.  Voltammetric amplified platform based on ionic liquid/NiO nanocomposite for determination of benserazide and levodopa , 2019, Journal of Molecular Liquids.

[34]  Huijun Zhao,et al.  Dramatically Enhanced Ambient Ammonia Electrosynthesis Performance by In‐Operando Created Li–S Interactions on MoS2 Electrocatalyst , 2019, Advanced Energy Materials.

[35]  Shasha Zheng,et al.  Ultrathin nanosheet-assembled [Ni3(OH)2(PTA)2(H2O)4]·2H2O hierarchical flowers for high-performance electrocatalysis of glucose oxidation reactions. , 2018, Nanoscale.

[36]  K. Mirica,et al.  Conductive two-dimensional metal-organic frameworks as multifunctional materials. , 2018, Chemical communications.

[37]  H. Karimi-Maleh,et al.  Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle , 2018 .

[38]  Huijuan Wang,et al.  Electrochemical sensor based on palladium-reduced graphene oxide modified with gold nanoparticles for simultaneous determination of acetaminophen and 4-aminophenol. , 2018, Talanta.

[39]  Hao Guo,et al.  Gold nanoparticles/tetraaminophenyl porphyrin functionalized multiwalled carbon nanotubes nanocomposites modified glassy carbon electrode for the simultaneous determination of p-acetaminophen and p-aminophenol , 2017 .

[40]  Zhiyong Tang,et al.  Ultrathin metal–organic framework nanosheets for electrocatalytic oxygen evolution , 2016, Nature Energy.

[41]  Ki‐Hyun Kim,et al.  Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin. , 2016, Analytica chimica acta.

[42]  A. Abdollahpour,et al.  Simultaneous determination of paracetamol, 4-Aminophenol, 4-Chloroacetanilid, Benzyl alcohol,Benzaldehyde and EDTA by HPLC methodin paracetamol injection ampoule , 2016 .

[43]  Yanzhong Zhang,et al.  Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy , 2015, Scientific Reports.

[44]  Mehmet Lütfi Yola,et al.  A sensitive molecularly imprinted polymer based quartz crystal microbalance nanosensor for selective determination of lovastatin in red yeast rice. , 2015, Food chemistry.

[45]  Hua Zhang.  Ultrathin Two-Dimensional Nanomaterials. , 2015, ACS nano.

[46]  C. Sekar,et al.  A new strategy for simultaneous determination of 4-aminophenol, uric acid and nitrite based on a graphene/hydroxyapatite composite modified glassy carbon electrode , 2015 .

[47]  Peixun Xiong,et al.  Metal–organic frameworks: a new promising class of materials for a high performance supercapacitor electrode , 2014 .

[48]  Carmine Ciofi,et al.  Electrochemical Detection of p-Aminophenol by Flexible Devices Based on Multi-Wall Carbon Nanotubes Dispersed in Electrochemically Modified Nafion , 2014, Sensors.

[49]  Fei Xu,et al.  Highly Sensitive and Selective Determination of Dopamine in the Presence of Ascorbic Acid Using Gold Nanoparticles‐Decorated MoS2 Nanosheets Modified Electrode , 2013 .

[50]  M. Taher,et al.  Simultaneous determination of droxidopa and carbidopa using a carbon nanotubes paste electrode , 2013 .

[51]  Lan Wang,et al.  Electrochemical sensing based on layered MoS2–graphene composites , 2013 .

[52]  H. Beitollahi,et al.  Novel nanostructure-based electrochemical sensor for simultaneous determination of dopamine and acetaminophen , 2012 .

[53]  Yang Fan,et al.  Graphene–polyaniline composite film modified electrode for voltammetric determination of 4-aminophenol , 2011 .

[54]  J. Raoof,et al.  Electroanalysis and Simultaneous Determination of 6-Thioguanine in the Presence of Uric Acid and Folic Acid Using a Modified Carbon Nanotube Paste Electrode , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[55]  L. Kubota,et al.  A hemin-based molecularly imprinted polymer (MIP) grafted onto a glassy carbon electrode as a selective sensor for 4-aminophenol amperometric , 2011 .

[56]  Q. Ma,et al.  Electrochemical behavior and voltammetric determination of 4-aminophenol based on graphene–chitosan composite film modified glassy carbon electrode , 2010 .

[57]  A. Safavi,et al.  A Selective and Sensitive Method for Simultaneous Determination of Traces of Paracetamol and p-Aminophenol in Pharmaceuticals Using Carbon Ionic Liquid Electrode , 2008 .

[58]  H. Zare,et al.  Electrochemical Behavior of Ascorbic Acid at a 2,2'-[3,6-Dioxa-1,8-octanediylbis(nitriloethylidyne)]-bis-hydroquinone Carbon Paste Electrode , 2008, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[59]  Q. Chu,et al.  Rapid determination of acetaminophen and p-aminophenol in pharmaceutical formulations using miniaturized capillary electrophoresis with amperometric detection. , 2008, Analytica chimica acta.

[60]  M. Bloomfield.  A sensitive and rapid assay for 4-aminophenol in paracetamol drug and tablet formulation, by flow injection analysis with spectrophotometric detection. , 2002, Talanta.

[61]  Hsuan‐Jung Huang,et al.  Chemiluminescence detection of paracetamol by a luminol-permanganate based reaction , 2001 .

[62]  K. Sing.  Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984) , 1985 .