Cornea and sclera.

cesses affecting the cornea. Diagnosis and treatment of corneal disease de¬ mand an understanding of the events occurring in the reparative processes in the cornea. Widespread clinical interest has engendered intense re¬ search activity, and the resultant lit¬ erature is voluminous. The appli¬ cation of the techniques of electron microscopy, in particular, has given considerable aid to our understanding of corneal healing. This review will concentrate on re¬ search in the past two decades and is limited, in the main, to English lan¬ guage sources. The interest in corneal wound heal¬ ing extends back well into the 19th century. Early studies described basic events in corneal wound healing in excellent detail. A subsequent lull in research in this subject is evident un¬ til the 1940s, when a series of fine papers extending our knowledge ap¬ peared; many of these studies were the result of World War II research directed to the effects of noxious agents on the cornea. Periodic studies appeared in the 1950s describing ex¬ perimental histological and histochemical findings; application of the techniques of electron microscopy in the 1960s has added a new dimension