En Face Optical Coherence Tomography for Visualization of the Choroid.

BACKGROUND AND OBJECTIVE To assess posterior pole choroid patterns in healthy eyes using en face optical coherence tomography (OCT). PATIENTS AND METHODS This observational study included 154 healthy eyes of 77 patients who underwent en face OCT. The mean age of the patients was 31.2 years (standard deviation: 13 years); 40 patients were women, and 37 patients were men. En face imaging of the choroidal vasculature was assessed using an OCT Optovue RTVue (Optovue, Fremont, CA). To generate an appropriate choroid image, the best detectable vessels in Haller's layer below the retinal pigment epithelium surface parallel plane were selected. RESULTS Images of diverse choroidal vessel patterns at the posterior pole were observed and recorded with en face OCT. Five different patterns of Haller's layer with different occurrences were assessed. Pattern 1 (temporal herringbone) represented 49.2%, pattern 2 (branched from below) and pattern 3 (laterally diagonal) represented 14.2%, pattern 4 (doubled arcuate) was observed in 11.9%, and pattern 5 (reticular feature) was observed in 10.5% of the reference plane. CONCLUSION In vivo assessment of human choroid microvasculature in healthy eyes using en face OCT demonstrated five different patterns. The choroid vasculature pattern may play a role in the origin and development of neuroretinal pathologies, with potential importance in chorioretinal diseases and circulatory abnormalities.

[1]  M. Rispoli,et al.  MORPHOLOGIC DIFFERENCES, ACCORDING TO ETIOLOGY, IN PIGMENT EPITHELIAL DETACHMENTS BY MEANS OF EN FACE OPTICAL COHERENCE TOMOGRAPHY , 2011, Retina.

[2]  Y. Ikuno,et al.  Choroidal thickness in healthy Japanese subjects. , 2010, Investigative ophthalmology & visual science.

[3]  Soon-Sun Kwon,et al.  COMPARISON OF CHOROIDAL THICKNESS AMONG PATIENTS WITH HEALTHY EYES, EARLY AGE-RELATED MACULOPATHY, NEOVASCULAR AGE-RELATED MACULAR DEGENERATION, CENTRAL SEROUS CHORIORETINOPATHY, AND POLYPOIDAL CHOROIDAL VASCULOPATHY , 2011, Retina.

[4]  J. Sahel,et al.  Retinal and choroidal changes observed with ‘En face’ enhanced-depth imaging OCT in central serous chorioretinopathy , 2013, British Journal of Ophthalmology.

[5]  R. Spaide,et al.  A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. , 2009, American journal of ophthalmology.

[6]  M. Tso,et al.  Angioarchitecture of the human choroid. , 1987, Archives of ophthalmology.

[7]  Jennifer I. Lim,et al.  Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update. , 2003, Ophthalmology.

[8]  Robert F Mullins,et al.  Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[9]  R. Spaide,et al.  ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY OF THE CHOROID IN CENTRAL SEROUS CHORIORETINOPATHY , 2009, Retina.

[10]  Martin F. Kraus,et al.  En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy. , 2014, Ophthalmology.

[11]  Richard F Spaide,et al.  Optical coherence tomography: imaging of the choroid and beyond. , 2013, Survey of ophthalmology.

[12]  P A Keane,et al.  Imaging chorioretinal vascular disease , 2010, Eye.

[13]  Boris Hermann,et al.  Wide-field optical coherence tomography of the choroid in vivo. , 2008, Investigative ophthalmology & visual science.

[14]  Justin Pedro,et al.  Multidimensional en-face OCT imaging of the retina. , 2009, Optics express.

[15]  Andrzej W. Fryczkowski,et al.  Anatomical and functional choroidal lobuli , 2004, International Ophthalmology.

[16]  J. Slakter,et al.  Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. , 2009, American journal of ophthalmology.

[17]  M. Mokhtari-Dizaji,et al.  Noninvasive estimation of the ocular elastic modulus for age-related macular degeneration in the human eye using sequential ultrasound imaging. , 2012, Ultrasonics.

[18]  Clinical infrared absorption angiography of the choroid. , 1972, American journal of ophthalmology.

[19]  Richard F Spaide,et al.  Age-related choroidal atrophy. , 2009, American journal of ophthalmology.