AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

[1]  T. Liang,et al.  Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth , 2022, Nature Cell Biology.

[2]  Yibo Gao,et al.  A non‐metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11‐mediated CD133 stability , 2022, Cancer communications.

[3]  Y. Tong,et al.  Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα. , 2022, Cell metabolism.

[4]  G. Semenza,et al.  Hypoxia-inducible factors: cancer progression and clinical translation , 2022, The Journal of clinical investigation.

[5]  R. Liu,et al.  Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth , 2021, bioRxiv.

[6]  H. Ding,et al.  ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction , 2021, Cell reports.

[7]  Wilhelm Palm.  Metabolic plasticity allows cancer cells to thrive under nutrient starvation , 2021, Proceedings of the National Academy of Sciences.

[8]  Kathleen M. Jagodnik,et al.  Gene Set Knowledge Discovery with Enrichr , 2021, Current protocols.

[9]  E. Ruppin,et al.  Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression , 2021, Cancer Research.

[10]  G. Bergers,et al.  The metabolism of cancer cells during metastasis , 2021, Nature Reviews Cancer.

[11]  O. Sansom,et al.  Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy , 2021, Nature Communications.

[12]  Sun-Mi Park,et al.  High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. , 2020, Cell metabolism.

[13]  M. Mann,et al.  Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. , 2020, Cancer discovery.

[14]  S. Sivanand,et al.  Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. , 2019, Cell metabolism.

[15]  O. Fiehn,et al.  Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway. , 2019, Cancer research.

[16]  Jill S Barnholtz-Sloan,et al.  CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. , 2018, Neuro-oncology.

[17]  M. Weirauch,et al.  AMP Kinase Promotes Glioblastoma Bioenergetics and Tumor Growth , 2018, Nature Cell Biology.

[18]  G. Mills,et al.  EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. , 2018, Molecular cell.

[19]  M. Goiny,et al.  PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis. , 2017, Cell reports.

[20]  Marie Strickland,et al.  Metabolic Reprogramming in Glioma , 2017, Front. Cell Dev. Biol..

[21]  Shuyi Zhang,et al.  ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway , 2017, Molecular Cancer.

[22]  Matthew G. Vander Heiden,et al.  Understanding the Intersections between Metabolism and Cancer Biology , 2017, Cell.

[23]  S. Wingert,et al.  AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis , 2017, Circulation research.

[24]  Deric M. Park,et al.  Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition , 2017, EMBO reports.

[25]  E. Laczko,et al.  Brain interstitial fluid glutamine homeostasis is controlled by blood–brain barrier SLC7A5/LAT1 amino acid transporter , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  Karen H. Vousden,et al.  Serine and one-carbon metabolism in cancer , 2016, Nature Reviews Cancer.

[27]  L. Linares,et al.  Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. , 2016, Molecular cell.

[28]  I. Nakano,et al.  Correction: Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells , 2016, PLoS biology.

[29]  R. Deberardinis,et al.  NRF2 regulates serine biosynthesis in non-small cell lung cancer , 2015, Nature Genetics.

[30]  Taotao Lao,et al.  AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol , 2015, Cell cycle.

[31]  Libing Song,et al.  cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions , 2015, Cell Research.

[32]  Ting Liu,et al.  Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovarian cancer in vitro , 2014, Journal of Ovarian Research.

[33]  F. Cecconi,et al.  Oxidative stress and autophagy: the clash between damage and metabolic needs , 2014, Cell Death and Differentiation.

[34]  I. Amelio,et al.  Serine and glycine metabolism in cancer☆ , 2014, Trends in biochemical sciences.

[35]  Andreas Krämer,et al.  Causal analysis approaches in Ingenuity Pathway Analysis , 2013, Bioinform..

[36]  Yunhong Zha,et al.  The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. , 2013, Cell metabolism.

[37]  Z. Oltvai,et al.  Abstract C151: Contribution of serine, folate, and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells. , 2013 .

[38]  Xuelin Huang,et al.  An improvement of the 2ˆ(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. , 2013, Biostatistics, bioinformatics and biomathematics.

[39]  Aleksey A. Porollo,et al.  Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis , 2013, Cell.

[40]  Karen Blyth,et al.  Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells , 2012, Nature.

[41]  Gregory Stephanopoulos,et al.  Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis , 2012, BMC Proceedings.

[42]  Abhishek K. Jha,et al.  Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer , 2011 .

[43]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[44]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[45]  R. Shaw,et al.  The LKB1–AMPK pathway: metabolism and growth control in tumour suppression , 2009, Nature Reviews Cancer.

[46]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[47]  N. Denko,et al.  Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.

[48]  Deric M. Park,et al.  N-CoR Pathway Targeting Induces Glioblastoma Derived Cancer Stem Cell Differentiation , 2007, Cell cycle.

[49]  O. Warburg.  [Origin of cancer cells]. , 1956, Oncologia.

[50]  Deric M. Park,et al.  Isolation and Propagation of Glioma Stem Cells from Acutely Resected Tumors. , 2016, Methods in molecular biology.

[51]  Huaiyu Mi,et al.  PANTHER pathway: an ontology-based pathway database coupled with data analysis tools. , 2009, Methods in molecular biology.

[52]  R. Deberardinis,et al.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.