论文信息 - ProPred: prediction of HLA-DR binding sites

ProPred: prediction of HLA-DR binding sites

UNLABELLED ProPred is a graphical web tool for predicting MHC class II binding regions in antigenic protein sequences. The server implement matrix based prediction algorithm, employing amino-acid/position coefficient table deduced from literature. The predicted binders can be visualized either as peaks in graphical interface or as colored residues in HTML interface. This server might be a useful tool in locating the promiscuous binding regions that can bind to several HLA-DR alleles. AVAILABILITY The server is available at http://www.imtech.res.in/raghava/propred/ CONTACT raghava@imtech.res.in SUPPLEMENTARY INFORMATION http://www.imtech.res.in/raghava/propred/page3.html

Gajendra P. S. Raghava | Harpreet Singh | Gajendra P.S. Raghava | H. Singh

[1] L Raddrizzani,et al. In Vitro and In Vivo Induction of a Th Cell Response Toward Peptides of the Melanoma-Associated Glycoprotein 100 Protein Selected by the TEPITOPE Program1 , 2000, The Journal of Immunology.

[2] F. Sinigaglia,et al. HLA class II peptide binding specificity and autoimmunity. , 1997, Advances in immunology.

[3] U. Şahin,et al. Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices , 1999, Nature Biotechnology.

[4] Matteo Bellone,et al. Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11 , 1999, The Journal of experimental medicine.