Functional analysis of human microsomal epoxide hydrolase genetic variants.

[1]  M. Eichelbaum,et al.  Distribution of Microsomal Epoxide Hydrolase in Humans: An Immunohistochemical Study in Normal Tissues, and Benign and Malignant Tumours , 2001, The Histochemical Journal.

[2]  T. Kohno,et al.  Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples , 2003, Journal of Human Genetics.

[3]  I. Cascorbi.  Pharmacogenetics of cytochrome P4502D6: genetic background and clinical implication , 2003, European journal of clinical investigation.

[4]  K Trieb,et al.  Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk , 2003, British Journal of Cancer.

[5]  K. Buetow,et al.  Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. , 2003, Cancer research.

[6]  Jong Y. Park,et al.  Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype. , 2003, Oral oncology.

[7]  S. Ishida,et al.  Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects , 2003, Xenobiotica; the fate of foreign compounds in biological systems.

[8]  E. Arndt.  Pharmacogenetics of cytochrome P 4502 D 6 : genetic background and clinical implication , 2003 .

[9]  Ulrich M. Zanger,et al.  Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry , 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

[10]  K. Buetow,et al.  Susceptibility to Aflatoxin B 1-related Primary Hepatocellular Carcinoma in Mice and Humans , 2003 .

[11]  Paolo Boffetta,et al.  Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review , 2002, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[12]  D. Eaton,et al.  Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[13]  C. Ulrich,et al.  Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[14]  P. van’t Veer,et al.  Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  A. Sekine,et al.  Seventy genetic variations in human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese population , 2001, Journal of Human Genetics.

[16]  S. Z. Abdel‐Rahman,et al.  Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. , 2001, Carcinogenesis.

[17]  C J Omiecinski,et al.  Epoxide hydrolases: biochemistry and molecular biology. , 2000, Chemico-biological interactions.

[18]  J. Meijer,et al.  Identification and Functional Characterization of Human Soluble Epoxide Hydrolase Genetic Polymorphisms* , 2000, The Journal of Biological Chemistry.

[19]  C. Smith,et al.  Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population. , 2000, Toxicology letters.

[20]  H. Whittle,et al.  Environmental and genetic determinants of aflatoxin–albumin adducts in The Gambia , 2000, International journal of cancer.

[21]  C-Y Chen,et al.  Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma , 2000, British Journal of Cancer.

[22]  M. Relling,et al.  Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. , 1999, Journal of the National Cancer Institute.

[23]  W. Evans,et al.  Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C. , 1999, Pharmacogenetics.

[24]  F. Gonzalez,et al.  Targeted Disruption of the Microsomal Epoxide Hydrolase Gene , 1999, The Journal of Biological Chemistry.

[25]  M. Sogorb,et al.  Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity. , 1999, Chemico-biological interactions.

[26]  N. Vermeulen,et al.  Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. , 1999, Critical reviews in toxicology.

[27]  E. Everett,et al.  Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization , 1999, Cytogenetic and Genome Research.

[28]  C. J. Omiecinski,et al.  Post-transcriptional regulation of human microsomal epoxide hydrolase. , 1998, Pharmacogenetics.

[29]  C. Hassett,et al.  Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms. , 1998, Carcinogenesis.

[30]  T. Guenthner,et al.  Co-purification of microsomal epoxide hydrolase with the warfarin-sensitive vitamin K1 oxide reductase of the vitamin K cycle. , 1998, Biochemical pharmacology.

[31]  F. Oesch,et al.  Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. , 1998, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[32]  D. Grant,et al.  Tissue-specific expression and alternative splicing of human microsomal epoxide hydrolase. , 1997, DNA and cell biology.

[33]  C. J. Omiecinski,et al.  Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression. , 1997, Archives of biochemistry and biophysics.

[34]  F. Oesch,et al.  Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide‐ but not from ethylene oxide‐induced DNA strand breaks , 1997, Environmental and molecular mutagenesis.

[35]  F. Gonzalez,et al.  Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. , 1996, Biochemistry.

[36]  M. Pirmohamed,et al.  Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene. , 1996, The Journal of pharmacology and experimental therapeutics.

[37]  R. H. Stellwagen,et al.  The Functional Expression of Sodium-dependent Bile Acid Transport in Madin-Darby Canine Kidney Cells Transfected with the cDNA for Microsomal Epoxide Hydrolase* , 1996, The Journal of Biological Chemistry.

[38]  M. Pirmohamed,et al.  Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity. , 1995, Biochemical pharmacology.

[39]  K. Buetow,et al.  Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[40]  F. Oesch,et al.  Induction of rat liver microsomal epoxide hydrolase by its endogenous substrate 16α, 17α-epoxyestra-1,3,5-trien-3-ol , 1995 .

[41]  F. Oesch,et al.  Induction of rat liver microsomal epoxide hydrolase by its endogenous substrate 16 alpha, 17 alpha-epoxyestra-1,3,5-trien-3-ol. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.

[42]  F. Oesch,et al.  Gene evolution of epoxide hydrolases and recommended nomenclature. , 1995, DNA and cell biology.

[43]  C. Hassett,et al.  The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. , 1994, Genomics.

[44]  D. Grant,et al.  Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. , 1994, Pharmacogenetics.

[45]  T. Rustan,et al.  Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes. , 1994, Human molecular genetics.

[46]  J. S. Sidhu,et al.  Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. , 1994, Human molecular genetics.

[47]  R. Holubkov,et al.  Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. , 1993, Pharmacogenetics.

[48]  R. Armstrong,et al.  Interaction of hepatic microsomal epoxide hydrolase derived from a recombinant baculovirus expression system with an azarene oxide and an aziridine substrate analogue. , 1993, Biochemistry.

[49]  O. Mcbride,et al.  Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. , 1988, The Journal of biological chemistry.

[50]  B. Hammock,et al.  Radiometric assays for mammalian epoxide hydrolases and glutathione S-transferase. , 1983, Analytical biochemistry.

[51]  D. Jerina,et al.  Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons. , 1977, Molecular pharmacology.

[52]  A. Y. Lu,et al.  Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes , 1977, Clinical pharmacology and therapeutics.

[53]  M. J. Coon,et al.  Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. , 1976, The Journal of biological chemistry.

[54]  A. Hewer,et al.  Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide , 1974, Nature.

[55]  Chemico-Biological Interactions , 2022 .