Comment on "Nanorobotics control design: a collective behavior approach for medicine".

The limitations on nanorobot design and activity imposed by Brownian motion events, communication problems, and the nature of the intercellular space are discussed. It is shown that severe problems exist for a nanorobot designed to enter tissues for therapeutic purposes when it is smaller than about 1 microm in any one of its dimensions.

[1]  J. Sturm,et al.  Tilted brownian ratchet for DNA analysis. , 2003, Analytical chemistry.

[2]  Tihamer T Toth-Fejel.  Agents, assemblers, and ANTS: scheduling assembly with market and biological software mechanisms , 2000 .

[3]  D. Scheinberg,et al.  Tumor Therapy with Targeted Atomic Nanogenerators , 2001, Science.

[4]  P. Cossart.  Bacterial invasion: a new strategy to dominate cytoskeleton plasticity. , 2004, Developmental cell.

[5]  L. Geppert,et al.  The amazing vanishing transistor act , 2002 .

[6]  Freitas Robert A.Jr.  CURRENT STATUS OF NANOMEDICINE AND MEDICAL NANOROBOTICS , 2005 .

[7]  Brent D. Cameron,et al.  Within a Nanometer of your Life , 2001 .

[8]  P. Hänggi,et al.  Nonlinear signal mixing in a ratchet device , 2004 .

[9]  K. Hamad-Schifferli,et al.  Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna , 2002, Nature.

[10]  R. Weiss,et al.  Directed evolution of a genetic circuit , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Pascale Cossart,et al.  Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens , 2004, Science.

[12]  M. Brightman,et al.  THE DISTRIBUTION WITHIN THE BRAIN OF FERRITIN INJECTED INTO CEREBROSPINAL FLUID COMPARTMENTS , 1965, The Journal of cell biology.

[13]  J. Carson,et al.  Bacterial Penetration of Bladder Epithelium through Lipid Rafts* , 2004, Journal of Biological Chemistry.

[14]  Leonard M. Adleman,et al.  On constructing a molecular computer , 1995, DNA Based Computers.