DNA methylation and cancer.

[1]  D. Cooper,et al.  The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions , 1990, Human Genetics.

[2]  B. Horsthemke,et al.  Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma , 1989, Human Genetics.

[3]  Michael Krawczak,et al.  Cytosine methylation and the fate of CpG dinucleotides in vertebrate genomes , 1989, Human Genetics.

[4]  David N. Cooper,et al.  The CpG dinucleotide and human genetic disease , 1988, Human Genetics.

[5]  R. Kerbel,et al.  On a possible epigenetic mechanism(s) of tumor cell heterogeneity , 2004, Cancer and Metastasis Reviews.

[6]  D. Cooper,et al.  DNA restriction fragment length polymorphisms and heterozygosity in the human genome , 2004, Human Genetics.

[7]  G. Lozano,et al.  Analysis of p53 mutants for transcriptional activity , 1991, Molecular and cellular biology.

[8]  J. Wands,et al.  p53 mutation in hepatocellular carcinoma after aflatoxin exposure , 1991, The Lancet.

[9]  T. Cebula,et al.  DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. , 1991, Science.

[10]  T. Crook,et al.  p53 is frequently mutated in Burkitt's lymphoma cell lines. , 1991, The EMBO journal.

[11]  V. Sheffield,et al.  Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Margaret Robertson,et al.  Identification and characterization of the familial adenomatous polyposis coli gene , 1991, Cell.

[13]  K. Kinzler,et al.  Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. , 1991, Science.

[14]  J. McPherson,et al.  Identification of deletion mutations and three new genes at the familial polyposis locus , 1991, Cell.

[15]  S. Altschul,et al.  Identification of FAP locus genes from chromosome 5q21. , 1991, Science.

[16]  B. Vogelstein,et al.  Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas. , 1991, Journal of the National Cancer Institute.

[17]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[18]  J. Minna,et al.  Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines. , 1991, Journal of the National Cancer Institute.

[19]  K. Münger,et al.  The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[20]  H. Shibata,et al.  Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors. , 1991, Biochemical and Biophysical Research Communications - BBRC.

[21]  G. Gaidano,et al.  p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Green,et al.  Identification of p53 gene mutations in bladder cancers and urine samples. , 1991, Science.

[23]  S. Baylin,et al.  High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Wands,et al.  Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa , 1991, Nature.

[25]  R. A. Metcalf,et al.  Mutational hot spot in the p53 gene in human hepatocellular carcinomas , 1991, Nature.

[26]  B. Vogelstein A deadly inheritance , 1990, Nature.

[27]  R Montesano,et al.  Frequent mutation of the p53 gene in human esophageal cancer. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[28]  W. Blattner,et al.  Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome , 1990, Nature.

[29]  L. Strong,et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.

[30]  A. Feinberg,et al.  Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts. , 1990, Science.

[31]  W. Bodmer,et al.  p53 mutations in colorectal cancer. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Haas,et al.  Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines , 1990, Molecular and cellular biology.

[33]  G. Coetzee,et al.  5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. , 1990, Science.

[34]  G. Chader,et al.  Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene. , 1990, Nucleic acids research.

[35]  Margaret Robertson,et al.  The neurofibromatosis type 1 gene encodes a protein related to GAP , 1990, Cell.

[36]  A. Bird,et al.  High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines , 1990, Cell.

[37]  W. Cavenee,et al.  Mechanisms of p53 loss in human sarcomas. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Robert L. Tanguay,et al.  In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. , 1990, Genes & development.

[39]  Jeng-Shin Lee,et al.  Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[40]  A. Bird,et al.  The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[41]  D. J. Driscoll,et al.  Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations , 1990, Somatic cell and molecular genetics.

[42]  A. Harris,et al.  Increased expression of mutant forms of p53 oncogene in primary lung cancer , 1990, The Lancet.

[43]  T. Kunkel,et al.  A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. , 1990, Biochemistry.

[44]  A. Poustka,et al.  Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping , 1990, Nature.

[45]  D. Housman,et al.  Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus , 1990, Cell.

[46]  R. Myers,et al.  Structure and variability of human chromosome ends , 1990, Molecular and cellular biology.

[47]  Kathleen R. Cho,et al.  Identification of a chromosome 18q gene that is altered in colorectal cancers. , 1990, Science.

[48]  J. Buckley,et al.  The role of DNA methylation in cancer. , 1990, Advances in cancer research.

[49]  B. Wold,et al.  In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. , 1990, Science.

[50]  E. Buckley,et al.  Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. , 1989, The New England journal of medicine.

[51]  F. Collins,et al.  Mutations in the p53 gene occur in diverse human tumour types , 1989, Nature.

[52]  A. Bird,et al.  Specific protection of methylated CpGs in mammalian nuclei , 1989, Cell.

[53]  F. Becker,et al.  In vitro DNA cytosine methylation of cis-regulatory elements modulates c-Ha-ras promoter activity in vivo. , 1989, Nucleic acids research.

[54]  J. Jiricny,et al.  In vitro correction of G o T mispairs to G o C pairs in nuclear extracts from human cells , 1989, Nature.

[55]  W. Doerfler,et al.  Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[56]  D. Ledbetter,et al.  Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. , 1989, Science.

[57]  J A Koziol,et al.  Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[58]  J. Jiricny,et al.  A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Harris,et al.  Deletion and hypermethylation of thymidine kinase gene in V79 Chinese hamster cells resistant to bromodeoxyuridine , 1988, Somatic cell and molecular genetics.

[60]  F. Grosveld,et al.  Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain , 1988, Molecular and cellular biology.

[61]  J. Jiricny,et al.  Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells , 1988, Cell.

[62]  S. Baylin,et al.  The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[63]  B. Glickman,et al.  Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells , 1988, Somatic cell and molecular genetics.

[64]  G. Pfeifer,et al.  DNA methylation levels in acute human leukemia. , 1988, Cancer letters.

[65]  B. Migeon,et al.  Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA. , 1988, The EMBO journal.

[66]  M. Lieb,et al.  Bacterial genes mutL, mutS, and dcm participate in repair of mismatches at 5-methylcytosine sites , 1987, Journal of bacteriology.

[67]  P. Jeggo,et al.  Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants. , 1987, Genes & development.

[68]  S. Tweedie,et al.  Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues. , 1987, Genes & development.

[69]  M. Frommer,et al.  CpG islands in vertebrate genomes. , 1987, Journal of molecular biology.

[70]  S. Hinrichs,et al.  Structural evidence for the authenticity of the human retinoblastoma gene. , 1987, Science.

[71]  A. Geiser,et al.  Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression. , 1987, Science.

[72]  A. Bird,et al.  Non‐methylated CpG‐rich islands at the human alpha‐globin locus: implications for evolution of the alpha‐globin pseudogene. , 1987, The EMBO journal.

[73]  G. Martin,et al.  Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation , 1987, Cell.

[74]  E. Stanbridge,et al.  Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells. , 1986, The EMBO journal.

[75]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[76]  Keith C. Norris,et al.  DNA cytosine methylation and heat-induced deamination , 1986, Bioscience reports.

[77]  C. Caskey,et al.  Methylation of the mouse hprt gene differs on the active and inactive X chromosomes , 1986, Molecular and cellular biology.

[78]  M. Radman,et al.  Mismatch repair in Escherichia coli. , 1986, Annual review of genetics.

[79]  H. Cedar,et al.  Effect of regional DNA methylation on gene expression. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[80]  A. Feinberg,et al.  Hypomethylation of DNA from benign and malignant human colon neoplasms. , 1985, Science.

[81]  B. Migeon,et al.  Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes , 1985, Nature.

[82]  M. Gouy,et al.  Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee. , 1985, Journal of molecular biology.

[83]  Donald Macleod,et al.  A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA , 1985, Cell.

[84]  S. S. Smith,et al.  The tumorigenicity of 5-azacytidine in the male Fischer rat. , 1984, Carcinogenesis.

[85]  E. E. Max,et al.  CG dinucleotide clusters in MHC genes and in 5' demethylated genes. , 1984, Nucleic acids research.

[86]  A. Bird Gene expression: DNA methylation — how important in gene control? , 1984, Nature.

[87]  D. Barker,et al.  Restriction sites containing CpG show a higher frequency of polymorphism in human DNA , 1984, Cell.

[88]  M. Ehrlich,et al.  The 5-methylcytosine content of DNA from human tumors. , 1983, Nucleic acids research.

[89]  J. Hurst,et al.  DNA methylation and the regulation of globin gene expression , 1983, Cell.

[90]  V. L. Wilson,et al.  DNA methylation decreases in aging but not in immortal cells. , 1983, Science.

[91]  J. Miller,et al.  Base substitution mutations induced by metabolically activated aflatoxin B1. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[92]  A. Bird,et al.  Unmethylated domains in vertebrate DNA. , 1983, Nucleic acids research.

[93]  Peter A. Jones,et al.  Inhibition of DNA methylation by chemical carcinogens in vitro , 1983, Cell.

[94]  A. Feinberg,et al.  Hypomethylation distinguishes genes of some human cancers from their normal counterparts , 1983, Nature.

[95]  A. Riggs,et al.  5-methylcytosine, gene regulation, and cancer. , 1983, Advances in cancer research.

[96]  A. Knudson Model hereditary cancers of man. , 1983, Progress in nucleic acid research and molecular biology.

[97]  M. Z. Humayun,et al.  Sequence specificity in aflatoxin B1--DNA interactions. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[98]  S. Goldstein,et al.  Interclonal variation in methylation patterns for expressed and non-expressed genes. , 1982, Nucleic acids research.

[99]  M. Harris Induction of thymidine kinase in enzyme-deficient chinese hamster cells , 1982, Cell.

[100]  P. Yen,et al.  Transformation with DNA from 5-azacytidine-reactivated X chromosomes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[101]  R. Palmiter,et al.  DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells , 1981, Cell.

[102]  P. Jones,et al.  Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. , 1981, Nucleic acids research.

[103]  M. Ehrlich,et al.  5-Methylcytosine in eukaryotic DNA. , 1981, Science.

[104]  T. Mohandas,et al.  Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. , 1981, Science.

[105]  Jeffrey H. Miller,et al.  Mutagenic deamination of cytosine residues in DNA , 1980, Nature.

[106]  R. Holliday,et al.  A new theory of carcinogenesis , 1979, British Journal of Cancer.

[107]  T. Lindahl,et al.  DNA glycosylases, endonucleases for apurinic/apyrimidinic sites, and base excision-repair. , 1979, Progress in nucleic acid research and molecular biology.

[108]  Philip J. Farabaugh,et al.  Molecular basis of base substitution hotspots in Escherichia coli , 1978, Nature.

[109]  R. Elton,et al.  Doublet frequency analysis of fractionated vertebrate nuclear DNA. , 1976, Journal of molecular biology.

[110]  Arthur D. Riggs,et al.  X inactivation, differentiation, and DNA methylation. , 1975, Cytogenetics and cell genetics.