Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer
暂无分享,去创建一个
Gary D Bader | J. Montero | A. Pandiella | V. Voisin | G. Serrano-Heras | A. Ocaña | M. D. Cuenca-López | L. Núñez | F. Morís | V. Corrales-Sánchez | M. Gómez-Juárez | M. J. Gascón-Escribano | Jorge Carlos Morales
[1] A. Esparís-Ogando,et al. Therapeutic potential of ERK5 targeting in triple negative breast cancer , 2014, Oncotarget.
[2] J. Montero,et al. Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer , 2014, Oncogene.
[3] Funda Meric-Bernstam,et al. Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes , 2013, Clinical Cancer Research.
[4] R. Greil,et al. Randomized phase II study of the anti-epidermal growth factor receptor monoclonal antibody cetuximab with cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[5] Irmtraud M. Meyer,et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers , 2012, Nature.
[6] Mithat Gönen,et al. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. , 2011, The Journal of clinical investigation.
[7] X. Chen,et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. , 2011, The Journal of clinical investigation.
[8] M. Rao,et al. Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase , 2011, Cell.
[9] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[10] David R. Croucher,et al. Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. , 2010, Cancer research.
[11] J. Montero,et al. Effect of multikinase inhibitors on caspase-independent cell death and DNA damage in HER2-overexpressing breast cancer cells. , 2010, Journal of the National Cancer Institute.
[12] Jingsong Yuan,et al. Focus on histone variant H2AX: To be or not to be , 2010, FEBS letters.
[13] T. Chou. Drug combination studies and their synergy quantification using the Chou-Talalay method. , 2010, Cancer research.
[14] Antonio Pineda-Lucena,et al. Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles. , 2009, Chemical communications.
[15] Charles M. Perou,et al. Triple-Negative Breast Cancer: Risk Factors to Potential Targets , 2008, Clinical Cancer Research.
[16] Boyoung Lee,et al. Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock , 2008, Molecular and Cellular Neuroscience.
[17] J Wade Harper,et al. The DNA damage response: ten years after. , 2007, Molecular cell.
[18] S. Narod,et al. Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence , 2007, Clinical Cancer Research.
[19] R. Beroukhim,et al. Molecular definition of breast tumor heterogeneity. , 2007, Cancer cell.
[20] Wolfgang Heller,et al. Triple-negative breast cancer: therapeutic options. , 2007, The Lancet. Oncology.
[21] A. Ashworth,et al. Hallmarks of 'BRCAness' in sporadic cancers , 2004, Nature Reviews Cancer.
[22] A. Gown,et al. Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma , 2004, Clinical Cancer Research.
[23] L. Bégin,et al. Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. , 2004, Journal of the National Cancer Institute.
[24] S. Morrison,et al. Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[25] R. Tibshirani,et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[26] T. Hunter,et al. Oncogenic kinase signalling , 2001, Nature.
[27] M. Kastan,et al. The many substrates and functions of ATM , 2000, Nature Reviews Molecular Cell Biology.
[28] J. Schlessinger. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[29] S. Elledge,et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[30] Christian A. Rees,et al. Molecular portraits of human breast tumours , 2000, Nature.
[31] Joseph Schlessinger,et al. Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.
[32] J. Schlessinger,et al. Signaling by Receptor Tyrosine Kinases , 1993 .